Journal article
Transient acidosis while retrieving a fear-related memory enhances its lability
eLife, Vol.6, e22564
06/26/2017
DOI: 10.7554/eLife.22564
PMCID: PMC5484615
PMID: 28650315
Abstract
Attenuating the strength of fearful memories could benefit people disabled by memories of past trauma. Pavlovian conditioning experiments indicate that a retrieval cue can return a conditioned aversive memory to a labile state. However, means to enhance retrieval and render a memory more labile are unknown. We hypothesized that augmenting synaptic signaling during retrieval would increase memory lability. To enhance synaptic transmission, mice inhaled CO
to induce an acidosis and activate acid sensing ion channels. Transient acidification increased the retrieval-induced lability of an aversive memory. The labile memory could then be weakened by an extinction protocol or strengthened by reconditioning. Coupling CO
inhalation to retrieval increased activation of amygdala neurons bearing the memory trace and increased the synaptic exchange from Ca
-impermeable to Ca
-permeable AMPA receptors. The results suggest that transient acidosis during retrieval renders the memory of an aversive event more labile and suggest a strategy to modify debilitating memories.
Details
- Title: Subtitle
- Transient acidosis while retrieving a fear-related memory enhances its lability
- Creators
- Jianyang Du - Department of Biological Sciences, University of Toledo, Toledo, United StatesMargaret P Price - Departments of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, United StatesRebecca J Taugher - Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, United StatesDaniel Grigsby - Departments of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, United StatesJamison J Ash - Departments of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, United StatesAustin C Stark - Departments of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, United StatesMd Zubayer Hossain Saad - Department of Biological Sciences, University of Toledo, Toledo, United StatesKritika Singh - Department of Biological Sciences, University of Toledo, Toledo, United StatesJuthika Mandal - Department of Biological Sciences, University of Toledo, Toledo, United StatesJohn A Wemmie - Department of Neurosurgery, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, United StatesMichael J Welsh - Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, United States
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.6, e22564
- Publisher
- England
- DOI
- 10.7554/eLife.22564
- PMID
- 28650315
- PMCID
- PMC5484615
- eISSN
- 2050-084X
- Grant note
- R01 DA037216 / NIDA NIH HHS R01 MH085724 / NIMH NIH HHS P01 HL051670 / NHLBI NIH HHS I01 BX000741 / BLRD VA Howard Hughes Medical Institute
- Language
- English
- Date published
- 06/26/2017
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Neurosurgery; Internal Medicine
- Record Identifier
- 9984066145302771
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