Journal article
Transient enalapril attenuates the reduction in glomerular filtration rate in prenatally programmed rats
Physiological reports, Vol.5(8), pp.e13266-n/a
04/01/2017
DOI: 10.14814/phy2.13266
PMCID: PMC5408291
PMID: 28438986
Abstract
A maternal low-protein diet has been shown to program hypertension and a reduction in glomerular filtration rate in adult offspring. This study examined the effect of continuous administration of enalapril in the drinking water and transient administration of enalapril administered from 21 to 42days of age on blood pressure and glomerular filtration rate (GFR) in male rats whose mothers were fed a 20% protein diet (control) or a 6% protein diet (programmed) during the last half of pregnancy. After birth all rats were fed a 20% protein diet. Programmed rats (maternal 6% protein diet) were hypertensive at 15 months of age compared to control rats and both continuous and transient administration of enalapril had no effect on blood pressure on control offspring, but normalized the blood pressure of programmed offspring. GFR was 3.2 +/- 0.1 mL/min in the control group and 1.7 +/- 0.1 mL/min in the programmed rats at 17 months of age (P<0.001). The GFR was 3.0 +/- 0.1 mL/min in the control and 2.7 +/- 0.1 mL/min in the programmed group that received continuous enalapril in their drinking water showing that enalapril can prevent the decrease in GFR in programmed rats. Transient administration of enalapril had no effect on GFR in the control group (3.2 +/- 0.1 mL/min) and prevented the decrease in GFR in the programmed group (2.9 +/- 0.1 mL/min). In conclusion, transient exposure to enalapril for 3 weeks after weaning can prevent the hypertension and decrease in GFR in prenatal programmed rats.
Details
- Title: Subtitle
- Transient enalapril attenuates the reduction in glomerular filtration rate in prenatally programmed rats
- Creators
- Asifhusen Mansuri - The University of Texas Southwestern Medical CenterAyah Elmaghrabi - The University of Texas Southwestern Medical CenterIssa Alhamoud - The University of Texas Southwestern Medical CenterSusan K. Legan - The University of Texas Southwestern Medical CenterJyothsna Gattineni - The University of Texas Southwestern Medical CenterMichel Baum - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- Physiological reports, Vol.5(8), pp.e13266-n/a
- DOI
- 10.14814/phy2.13266
- PMID
- 28438986
- PMCID
- PMC5408291
- NLM abbreviation
- Physiol Rep
- ISSN
- 2051-817X
- eISSN
- 2051-817X
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- DK-41612; DK078596; 1P30DK079328-01 / National Institutes of Health Grants; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Children's Clinical Research Advisory Committee (CCRAC) from Children's Health of Dallas
- Language
- English
- Date published
- 04/01/2017
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984353843102771
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