Journal article
Transient improvement of congenital lactic acidosis in a male infant with pyruvate decarboxylase deficiency treated with dichloroacetate
The Journal of pediatrics, Vol.123(3), pp.427-430
1993
DOI: 10.1016/S0022-3476(05)81751-2
PMID: 8355121
Abstract
A comatose male newborn infant with congenital lactic acidosis caused by pyruvate decarboxylase deficiency was treated with dichloroacetate (DCA), which stimulated an 88% drop in serum lactate concentration and reversed his coma. The response to DCA was temporary and the lactic acidosis worsened until his death, but DCA may confer more lasting benefit in less severely affected infants.
Details
- Title: Subtitle
- Transient improvement of congenital lactic acidosis in a male infant with pyruvate decarboxylase deficiency treated with dichloroacetate
- Creators
- Peter P. Tóth - University of IowaHatem El-Shanti - University of IowaSandra Eivins - University of IowaWilliam J. Rhead - University of IowaJonathan M. Klein - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.123(3), pp.427-430
- Publisher
- Mosby, Inc
- DOI
- 10.1016/S0022-3476(05)81751-2
- PMID
- 8355121
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Language
- English
- Date published
- 1993
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics; Neonatology
- Record Identifier
- 9984353938902771
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