Translating MSC Therapy in the Age of Obesity

Lauren Boland; Laura Melanie Bitterlich; Andrew E. Hogan; James A. Ankrum; Karen English

doi:10.3389/fimmu.2022.943333

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Translating MSC Therapy in the Age of Obesity

Journal article

Open access

Peer reviewed

Translating MSC Therapy in the Age of Obesity

Lauren Boland, Laura Melanie Bitterlich, Andrew E. Hogan, James A. Ankrum and Karen English

Frontiers in immunology, Vol.13, 943333

07/01/2022

DOI: 10.3389/fimmu.2022.943333

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Abstract

Mesenchymal stromal cell (MSC) therapy has seen increased attention as a possible option to treat a number of inflammatory conditions including COVID-19 acute respiratory distress syndrome (ARDS). As rates of obesity and metabolic disease continue to rise worldwide, increasing proportions of patients treated with MSC therapy will be living with obesity. The obese environment poses critical challenges for immunomodulatory therapies that should be accounted for during development and testing of MSCs. In this review, we look to cancer immunotherapy as a model for the challenges MSCs may face in obese environments. We then outline current evidence that obesity alters MSC immunomodulatory function, drastically modifies the host immune system, and therefore reshapes interactions between MSCs and immune cells. Finally, we argue that obese environments may alter essential features of allogeneic MSCs and offer potential strategies for licensing of MSCs to enhance their efficacy in the obese microenvironment. Our aim is to combine insights from basic research in MSC biology and clinical trials to inform new strategies to ensure MSC therapy is effective for a broad range of patients.

Obesity

disease microenvironment

immunomodulation

mesenchymal stromal cells (MSCs)

metabolic disease

Details

Title: Subtitle: Translating MSC Therapy in the Age of Obesity
Creators: Lauren Boland - University of Iowa
Laura Melanie Bitterlich - National University of Ireland, Maynooth
Andrew E. Hogan - National University of Ireland, Maynooth
James A. Ankrum - University of Iowa
Karen English - National University of Ireland, Maynooth
Resource Type: Journal article
Publication Details: Frontiers in immunology, Vol.13, 943333
DOI: 10.3389/fimmu.2022.943333
eISSN: 1664-3224
Publisher: Frontiers Media S.A
Grant note: DOI: 10.13039/501100001602, name: Science Foundation Ireland; DOI: 10.13039/501100002081, name: Irish Research Council; DOI: 10.13039/100000002, name: National Institutes of Health
Language: English
Date published: 07/01/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Iowa Superfund Research Program
Record Identifier: 9984274760302771

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