Journal article
Translational Diagnostics and Therapeutics in Pancreatic Neuroendocrine Tumors
Clinical cancer research, Vol.22(20), pp.5022-5029
10/15/2016
DOI: 10.1158/1078-0432.CCR-16-0435
PMCID: PMC5082425
PMID: 27742788
Abstract
Pancreatic neuroendocrine tumors (PNET) are rare tumors, but have been increasing in incidence. Although typically thought of as indolent, more than half of patients present with metastatic disease. For many years, the only mutations commonly known in these tumors were those in the MEN1 gene. Recently, the genetics underlying PNETs have been further defined through exome sequencing. The most frequent alterations found in sporadic PNETs are in MEN1, DAXX/ATRX, and a variety of genes in the mTOR pathway. Confirmation of these mutations has prompted trials with a number of drugs active in these pathways, and two drugs were eventually approved in 2011-sunitinib and everolimus. New data additionally identify the MET and CD47 receptors as potential novel drug targets. Yet despite improvements in progression-free survival with sunitinib and everolimus, further studies defining when to use these agents and factors associated with limitations in their utility are needed. As more discoveries are made in the laboratory that elucidate additional molecular mechanisms important in the initiation and metastasis of PNETs, continued efforts to translate these discoveries into distinct new therapies will be needed to improve patient survival. Clin Cancer Res; 22(20); 5022-9. ©2016 AACR SEE ALL ARTICLES IN THIS CCR FOCUS SECTION, "ENDOCRINE CANCERS REVISING PARADIGMS".
Details
- Title: Subtitle
- Translational Diagnostics and Therapeutics in Pancreatic Neuroendocrine Tumors
- Creators
- Jessica E Maxwell - Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IowaScott K Sherman - Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IowaJames R Howe - Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa. james-howe@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Clinical cancer research, Vol.22(20), pp.5022-5029
- DOI
- 10.1158/1078-0432.CCR-16-0435
- PMID
- 27742788
- PMCID
- PMC5082425
- NLM abbreviation
- Clin Cancer Res
- ISSN
- 1078-0432
- eISSN
- 1557-3265
- Publisher
- United States
- Grant note
- P30 CA086862 / NCI NIH HHS T32 CA148062 / NCI NIH HHS P50 CA174521 / NCI NIH HHS
- Language
- English
- Date published
- 10/15/2016
- Academic Unit
- Surgery
- Record Identifier
- 9984051577602771
Metrics
13 Record Views