Journal article
Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion
Proceedings of the National Academy of Sciences - PNAS, Vol.113(26), pp.7243-7248
06/28/2016
DOI: 10.1073/pnas.1606537113
PMCID: PMC4932980
PMID: 27298354
Abstract
Drosophila larval locomotion, which entails rhythmic body contractions, is controlled by sensory feedback from proprioceptors. The molecular mechanisms mediating this feedback are little understood. By using genetic knock-in and immunostaining, we found that the Drosophila melanogaster transmembrane channel-like (tmc) gene is expressed in the larval class I and class II dendritic arborization (da) neurons and bipolar dendrite (bd) neurons, both of which are known to provide sensory feedback for larval locomotion. Larvae with knockdown or loss of tmc function displayed reduced crawling speeds, increased head cast frequencies, and enhanced backward locomotion. Expressing Drosophila TMC or mammalian TMC1 and/or TMC2 in the tmc-positive neurons rescued these mutant phenotypes. Bending of the larval body activated the tmc-positive neurons, and in tmc mutants this bending response was impaired. This implicates TMC's roles in Drosophila proprioception and the sensory control of larval locomotion. It also provides evidence for a functional conservation between Drosophila and mammalian TMCs.
Details
- Title: Subtitle
- Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion
- Creators
- Yanmeng Guo - Institute of Neuroscience, Chinese Academy of Sciences (CAS) Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Graduate School of University of Chinese Academy of Sciences, Beijing 100049, China; Department of Physiology, University of California, San Francisco, CA 94158; Department of Biochemistry, University of California, San Francisco, CA 94158; Department of Biophysics, University of California, San Francisco, CA 94158; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158Yuping Wang - Chinese Academy of SciencesWei Zhang - University of California, San FranciscoShan Meltzer - Department of Physiology, University of California, San Francisco, CA 94158; Department of Biochemistry, University of California, San Francisco, CA 94158; Department of Biophysics, University of California, San Francisco, CA 94158; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158Damiano Zanini - Department of Cellular Neurobiology, University of Göttingen, 37077 Goettingen, GermanyYue Yu - College of Biological Sciences, China Agricultural University, Beijing 100193, ChinaJiefu Li - Department of Physiology, University of California, San Francisco, CA 94158; Department of Biochemistry, University of California, San Francisco, CA 94158; Department of Biophysics, University of California, San Francisco, CA 94158; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158Tong Cheng - Department of Physiology, University of California, San Francisco, CA 94158; Department of Biochemistry, University of California, San Francisco, CA 94158; Department of Biophysics, University of California, San Francisco, CA 94158; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158Zhenhao Guo - Department of Physiology, University of California, San Francisco, CA 94158; Department of Biochemistry, University of California, San Francisco, CA 94158; Department of Biophysics, University of California, San Francisco, CA 94158; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158Qingxiu Wang - Chinese Academy of SciencesJulie S Jacobs - Department of Biology, The University of Iowa, Iowa City, IA 52242Yashoda Sharma - Department of Biology, The University of Iowa, Iowa City, IA 52242Daniel F Eberl - Department of Biology, The University of Iowa, Iowa City, IA 52242Martin C Göpfert - Department of Cellular Neurobiology, University of Göttingen, 37077 Goettingen, GermanyLily Yeh Jan - Department of Physiology, University of California, San Francisco, CA 94158; Department of Biochemistry, University of California, San Francisco, CA 94158; Department of Biophysics, University of California, San Francisco, CA 94158; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158Yuh Nung Jan - Department of Physiology, University of California, San Francisco, CA 94158; Department of Biochemistry, University of California, San Francisco, CA 94158; Department of Biophysics, University of California, San Francisco, CA 94158; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158; yuhnung.jan@ucsf.edu zuorenwang@ion.ac.cnZuoren Wang - Institute of Neuroscience, Chinese Academy of Sciences (CAS) Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; yuhnung.jan@ucsf.edu zuorenwang@ion.ac.cn
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.113(26), pp.7243-7248
- Publisher
- United States
- DOI
- 10.1073/pnas.1606537113
- PMID
- 27298354
- PMCID
- PMC4932980
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Grant note
- R37 NS040929 / NINDS NIH HHS R01 DC004848 / NIDCD NIH HHS R01 MH084234 / NIMH NIH HHS
- Language
- English
- Date published
- 06/28/2016
- Academic Unit
- Iowa Neuroscience Institute; Biology; Internal Medicine
- Record Identifier
- 9983992060502771
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