Journal article
Transmission of GB Virus Type C via Transfusion in a Cohort of HIV-Infected Patients
The Journal of infectious diseases, Vol.205(9), pp.1436-1442
05/01/2012
DOI: 10.1093/infdis/jis209
PMCID: PMC3324396
PMID: 22438325
Abstract
Background.
GB virus C (GBV-C) infection is transmitted by blood exposure and associated with lower human immunodeficiency virus (HIV) load and slower HIV disease progression. Few studies describe predictors of acute GBV-C infection following transfusion in HIV-infected patients.
Methods.
We used a limited-access database from the National Heart Lung and Blood Institute’s Viral Activation Transfusion Study, a randomized controlled trial of leukoreduced versus nonleukoreduced transfusions received by HIV-infected, transfusion-naive patients. Blood samples from 489 subjects were tested for GBV-C markers in pretransfusion and posttransfusion samples. We estimated the risk of acquiring GBV-C RNA and predictors of GBV-C acquisition, using pooled logistic regression.
Results.
GBV-C RNA was detected ≤120 days following the first transfusion in 22 (7.5%) of 294 subjects who were GBV-C negative before transfusion. The risk of GBV-C RNA acquisition increased with each unit transfused (odds ratio, 1.09; 95% confidence interval, 1.06–1.11). Lower baseline HIV load and use of antiretroviral therapy were associated with subsequent GBV-C RNA acquisition, after control for units of blood transfused. Leukoreduced status of transfused units was not associated with GBV-C transmission.
Conclusions.
Blood transfusion is associated with a significant risk of GBV-C acquisition among HIV-infected patients. Transmission of GBV-C by blood transfusion was inversely related to HIV load.
Details
- Title: Subtitle
- Transmission of GB Virus Type C via Transfusion in a Cohort of HIV-Infected Patients
- Creators
- F Vahidnia - Department of Epidemiology, Blood Systems Research Institute, San FranciscoM Petersen - Department of Biostatistics and Epidemiology, University of California, BerkeleyG Rutherford - Department of Epidemiology and Biostatistics, University of California, San FranciscoM Busch - Department of Epidemiology, Blood Systems Research Institute, San FranciscoS Assmann - New England Research Institutes, Watertown, MassachusettsJ. T Stapleton - Iowa City VA Medical Center, University of Iowa, Iowa CityB Custer - Department of Epidemiology, Blood Systems Research Institute, San Francisco
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.205(9), pp.1436-1442
- Publisher
- Oxford University Press
- DOI
- 10.1093/infdis/jis209
- PMID
- 22438325
- PMCID
- PMC3324396
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 05/01/2012
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094506602771
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