Journal article
Transmitted HIV Type 1 Drug Resistance Among Individuals with Recent HIV Infection in East and Southern Africa
AIDS research and human retroviruses, Vol.27(1), pp.5-12
01/01/2011
DOI: 10.1089/aid.2010.0030
PMCID: PMC3045073
PMID: 21091377
Abstract
To characterize WHO-defined transmitted HIV drug resistance mutation (TDRM) data from recently HIV-infected African volunteers, we sequenced HIV (
pol)
and evaluated for TDRM the earliest available specimens from ARV-naive volunteers diagnosed within 1 year of their estimated date of infection at eight research centers in sub-Saharan Africa. TDRMs were detected in 19/408 (5%) volunteers. The prevalence of TDRMs varied by research center, from 5/26 (19%) in Entebbe, 6/78 (8%) in Kigali, 2/49 (4%) in Kilifi, to 3/106 (3%) in Lusaka. One of five volunteers from Cape Town (20%) had TDRMs. Despite small numbers, our data suggest an increase in DRMs by year of infection in Zambia (
p
= 0.004). The prevalence observed in Entebbe was high across the entire study. ARV history data from 12 (63%) HIV-infected sexual partners were available; 3 reported ARV use prior to transmission. Among four partners with sequence data available, transmission linkage was confirmed and two had the same TDRMs as the newly infected volunteer (both K103N). As ARV therapy continues to increase in availability throughout Africa, monitoring incident virus strains for the presence of TDRMs should be a priority. Early HIV infection cohorts provide an excellent and important platform to monitor the development of TDRMs to inform treatment guidelines, drug choices, and strategies for secondary prevention of TDRM transmission.
Details
- Title: Subtitle
- Transmitted HIV Type 1 Drug Resistance Among Individuals with Recent HIV Infection in East and Southern Africa
- Creators
- Matt A. Price - International AIDS Vaccine InitiativeCarole L. Wallis - University of the WitwatersrandShabir Lakhi - Rwanda Zambia HIV Research GroupEtienne Karita - Rwanda Zambia HIV Research GroupAnatoli Kamali - Uganda Virus Research InstituteOmu Anzala - Kenya AIDS Vaccine InitiativeEduard J. Sanders - Kenya AIDS Vaccine InitiativeLinda-Gail Bekker - Desmond Tutu HIV FoundationRogers Twesigye - Uganda Virus Research InstituteEric Hunter - Rwanda Zambia HIV Research GroupPontiano Kaleebu - Kenya AIDS Vaccine InitiativeKayitesi Kayitenkore - Rwanda Zambia HIV Research GroupSusan Allen - Rwanda Zambia HIV Research GroupEugene Ruzagira - Uganda Virus Research InstituteMary Mwangome - Kenya Medical Research InstituteGaudensia Mutua - Kenya AIDS Vaccine InitiativePauli N. Amornkul - International AIDS Vaccine InitiativeGwynn Stevens - International AIDS Vaccine InitiativeSergei L.K. Pond - University of California, San DiegoMalinda Schaefer - Emory UniversityMary A. Papathanasopoulos - University of the WitwatersrandWendy Stevens - University of the WitwatersrandJill Gilmour - Kenya AIDS Vaccine InitiativeIAVI Early Infection Cohort Study
- Resource Type
- Journal article
- Publication Details
- AIDS research and human retroviruses, Vol.27(1), pp.5-12
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/aid.2010.0030
- PMID
- 21091377
- PMCID
- PMC3045073
- ISSN
- 0889-2229
- eISSN
- 1931-8405
- Language
- English
- Date published
- 01/01/2011
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984697044402771
Metrics
2 Record Views