Journal article
Transplantation of Neural Progenitor Cells into the Developing Retina of the Brazilian Opossum: An in vivo System for Studying Stem/Progenitor Cell Plasticity
Developmental Neuroscience, Vol.26(5-6), pp.336-345
04/2005
DOI: 10.1159/000082275
PMID: 15855762
Abstract
In developing cell transplant strategies to repair the diseased or injured retina is essential to consider host-graft interactions and how they may influence the outcome of the transplants. In the present study we evaluated the influence of the host microenvironment upon neural progenitor cells (NPCs) transplanted into the developing and mature retina of the Brazilian opossum, Monodelphis domestica. Monodelphis pups are born in an extremely immature state and the neonatal pups provide a fetal-like environment in which to study the interactions between host tissues and transplanted NPCs. Three different populations of GFP-expressing NPCs were transplanted by intraocular injection in hosts ranging in age from 5 days postnatal to adult. Extensive survival, differentiation and morphological integration of NPCs were observed within the developing retina. These results suggest that the age of the host environment can strongly influence NPC differentiation and integration.
Details
- Title: Subtitle
- Transplantation of Neural Progenitor Cells into the Developing Retina of the Brazilian Opossum: An in vivo System for Studying Stem/Progenitor Cell Plasticity
- Creators
- D.S SakaguchiS.J van HoffelenE TheuschE ParkerJ OraskyM.M HarperA BenediktssonM J Young - Harvard Medical School
- Resource Type
- Journal article
- Publication Details
- Developmental Neuroscience, Vol.26(5-6), pp.336-345
- Publisher
- Basel, Switzerland
- DOI
- 10.1159/000082275
- PMID
- 15855762
- eISBN
- 3318011827; 9783318011821
- ISSN
- 0378-5866
- eISSN
- 1421-9859
- Number of pages
- 10
- Language
- English
- Date published
- 04/2005
- Academic Unit
- Biology; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980086002771
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