Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing

Prathish K Rajaraman; Jiwoong Choi; Eric A Hoffman; Patrick T O'Shaughnessy; Sanghun Choi; Renishkumar Delvadia; Andrew Babiskin; Ross Walenga; Ching-Long Lin

doi:10.1016/j.jaerosci.2020.105581

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Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing

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Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing

Prathish K Rajaraman, Jiwoong Choi, Eric A Hoffman, Patrick T O'Shaughnessy, Sanghun Choi, Renishkumar Delvadia, Andrew Babiskin, Ross Walenga and Ching-Long Lin

Journal of aerosol science, Vol.146, pp.105581-105581

08/2020

DOI: 10.1016/j.jaerosci.2020.105581

PMID: 32346183

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Abstract

This study numerically investigates the effect of hygroscopicity on transport and deposition of particles in severe asthmatic lungs with distinct airway structures. The study human subjects were selected from two imaging-based severe asthmatic clusters with one characterized by non-constricted airways and the other by constricted airways in the lower left lobe (LLL). We compared the deposition fractions of sodium chloride (NaCl) particles with a range of aerodynamic diameters (1–8 μm) in cluster archetypes under conditions with and without hygroscopic growth. The temperature and water vapor distributions in the airways were simulated with an airway wall boundary condition that accounts for variable temperature and water vapor evaporation at the interface between the lumen and the airway surface liquid layer. On average, the deposition fraction increased by about 6% due to hygroscopic particle growth in the cluster subjects with constricted airways, while it increased by only about 0.5% in those with non-constricted airways. The effect of particle growth was most significant for particles with an initial diameter of 2μm in the cluster subjects with constricted airways. The effect diminished with increasing particle size, especially for particles with an initial diameter larger than 4 μm. This suggests the necessity to differentiate asthmatic subjects by cluster in engineering the aerosol size for tailored treatment. Specifically, the treatment of severe asthmatic subjects who have constricted airways with inhalation aerosols may need submicron-sized hygroscopic particles to compensate for particle growth, if one targets for delivering to the peripheral region. These results could potentially inform the choice of particle size for inhalational drug delivery in a cluster-specific manner. •Transport and deposition of dry NaCl particles in subject-specific asthma subjects.•Cluster asthma subjects based on airways constriction in the left lower lobe.•Comparing stable and hygroscopic growth particles in constricted airways.•Hygroscopic particle growth contributed more to the deposition fraction up to 3.5% higher in the LLL.

Cluster analysis

Particle deposition

Airway constriction

Computational fluid dynamics

Hygroscopic growth

Details

Title: Subtitle: Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing
Creators: Prathish K Rajaraman - Department of Mechanical Engineering, The University of Iowa, Iowa City, IA, USA
Jiwoong Choi - Department of Mechanical Engineering, The University of Iowa, Iowa City, IA, USA
Eric A Hoffman - Department of Radiology, The University of Iowa, Iowa City, IA, USA
Patrick T O'Shaughnessy - Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA, USA
Sanghun Choi - School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea
Renishkumar Delvadia - Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA
Andrew Babiskin - Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA
Ross Walenga - Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA
Ching-Long Lin - Department of Mechanical Engineering, The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Journal of aerosol science, Vol.146, pp.105581-105581
DOI: 10.1016/j.jaerosci.2020.105581
PMID: 32346183
NLM abbreviation: J Aerosol Sci
ISSN: 0021-8502
eISSN: 1879-1964
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100000038, name: FDA, award: U01-FD005837; DOI: 10.13039/100000002, name: NIH, award: U01-HL114494, P30ES005605; DOI: 10.13039/100000001, name: National Science Foundation, award: MCA07S015
Language: English
Date published: 08/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Civil and Environmental Engineering; Occupational and Environmental Health; IIHR--Hydroscience and Engineering; Mechanical Engineering; Internal Medicine
Record Identifier: 9984066337802771

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