Journal article
Transposon-based screens for cancer gene discovery in mouse models
Seminars in cancer biology, Vol.20(4), pp.261-268
2010
DOI: 10.1016/j.semcancer.2010.05.003
PMCID: PMC2940989
PMID: 20478384
Abstract
Significant emphasis has recently been placed on the characterization of the human cancer genome. This effort has been assisted by the development of new DNA sequencing technologies that allow the genomes of individual tumors to be analyzed in much greater detail. However, the genetic complexity of human cancer has complicated the identification of driver mutations among the more abundant passenger mutations found in tumors. Recently, the Sleeping Beauty (SB) transposon system has been engineered to model cancer in mice. SB-induced tumors are produced by transposon insertional mutagenesis, thus the tagged mutations facilitate the identification of novel cancer genes. This review provides a brief summary of the SB system and its use in modeling cancer in mice.
Details
- Title: Subtitle
- Transposon-based screens for cancer gene discovery in mouse models
- Creators
- Adam J Dupuy - Department of Anatomy & Cell Biology, Carver College of Medicine, University of Iowa, 1-400A BSB, 51 Newton Road, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Seminars in cancer biology, Vol.20(4), pp.261-268
- DOI
- 10.1016/j.semcancer.2010.05.003
- PMID
- 20478384
- PMCID
- PMC2940989
- NLM abbreviation
- Semin Cancer Biol
- ISSN
- 1044-579X
- eISSN
- 1096-3650
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2010
- Academic Unit
- Anatomy and Cell Biology; Pathology
- Record Identifier
- 9984025580802771
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