Journal article
Transverse relaxation rates of pulmonary dissolved-phase Hyperpolarized Xe-129 as a biomarker of lung injury in idiopathic pulmonary fibrosis
Magnetic resonance in medicine, Vol.84(4), pp.1857-1867
10/01/2020
DOI: 10.1002/mrm.28246
PMCID: PMC7329592
PMID: 32162357
Abstract
Purpose: The MR properties (chemical shifts and R-2*decay rates) of dissolved-phase hyperpolarized (HP)Xe-129 are confounded by the large magnetic field inhomogeneity present in the lung. This work improves measurements of these properties using a model-based image reconstruction to characterize the R-2* decay rates of dissolved-phase HP Xe-129 in healthy subjects and patients with idiopathic pulmonary fibrosis (IPF).
Methods: Whole-lung MRS and 3D radial MRI with four gradient echoes were performed after inhalation of HP Xe-129 in healthy subjects and patients with IPF. A model-based image reconstruction formulated as a regularized optimization problem was solved iteratively to measure regional signal intensity in the gas, barrier, and red blood cell (RBC) compartments, while simultaneously measuring their chemical shifts and R-2* decay rates.
Results: The estimation of spectral properties reduced artifacts in images of HP Xe-129 in the gas, barrier, and RBC compartments and improved image SNR by over 20%. R-2*decay rates of the RBC and barrier compartments were lower in patients with IPF compared to healthy subjects (P < 0.001 and P= 0.005, respectively) and correlated to DLCO (R = 0.71 and 0.64, respectively). Chemical shift of the RBC component measured with whole-lung spectroscopy was significantly different between IPF and normal subjects (P = 0.022).
Conclusion: Estimates for R-2* in both barrier and RBC dissolved-phase HP Xe-129 compartments using a regional signal model improved image quality for dissolved-phase images and provided additional biomarkers of lung injury in IPF.
Details
- Title: Subtitle
- Transverse relaxation rates of pulmonary dissolved-phase Hyperpolarized Xe-129 as a biomarker of lung injury in idiopathic pulmonary fibrosis
- Creators
- Jeff Kammerman - University of Wisconsin–MadisonAndrew D. Hahn - University of Wisconsin–MadisonRobert Cadman - University of Wisconsin–MadisonAnnelise Malkus - University of Wisconsin–MadisonDavid Mummy - Duke UniversitySean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.84(4), pp.1857-1867
- DOI
- 10.1002/mrm.28246
- PMID
- 32162357
- PMCID
- PMC7329592
- NLM abbreviation
- Magn Reson Med
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- UL1TR000427 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) Office of the Vice Chancellor for Research and Graduate Education at the University of Wisconsin, Madison RO1 HL126771 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) S10 OD016394 / Pulmonary Imaging Center GE Healthcare; General Electric
- Language
- English
- Date published
- 10/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275054502771
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