Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Samantha Bottom-Tanzer; Sofia Corella; Jochen Meyer; Mary Sommer; Luis Bolanos; Timothy Murphy; Sadi Quinones; Shane Heiney; Matthew Shtrahman; Michael Whalen; Rachel Oren; Michael J. Higley; Jessica A. Cardin; Farzad Noubary; Moritz Armbruster; Chris Dulla

doi:10.1093/cercor/bhae038

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Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Journal article

Peer reviewed

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, …

Cerebral cortex (New York, N.Y. 1991), Vol.34(2), 038

01/31/2024

DOI: 10.1093/cercor/bhae038

PMCID: PMC11486687

PMID: 38365273

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Abstract

Traumatic brain injury (TBI) is the leading cause of death in young people and can cause cognitive and motor dysfunction and disruptions in functional connectivity between brain regions. In human TBI patients and rodent models of TBI, functional connectivity is decreased after injury. Recovery of connectivity after TBI is associated with improved cognition and memory, suggesting an important link between connectivity and functional outcome. We examined widespread alterations in functional connectivity following TBI using simultaneous widefield mesoscale GCaMP7c calcium imaging and electrocorticography (ECoG) in mice injured using the controlled cortical impact (CCI) model of TBI. Combining CCI with widefield cortical imaging provides us with unprecedented access to characterize network connectivity changes throughout the entire injured cortex over time. Our data demonstrate that CCI profoundly disrupts functional connectivity immediately after injury, followed by partial recovery over 3 weeks. Examining discrete periods of locomotion and stillness reveals that CCI alters functional connectivity and reduces theta power only during periods of behavioral stillness. Together, these findings demonstrate that TBI causes dynamic, behavioral state-dependent changes in functional connectivity and ECoG activity across the cortex.

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Science & Technology

Details

Title: Subtitle: Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model
Creators: Samantha Bottom-Tanzer - Tufts University
Sofia Corella - Case Western Reserve University
Jochen Meyer - Baylor College of Medicine
Mary Sommer - Tufts University
Luis Bolanos - University of British Columbia
Timothy Murphy - University of British Columbia
Sadi Quinones - Tufts University
Shane Heiney - University of Iowa
Matthew Shtrahman - University of California San Diego
Michael Whalen - Massachusetts General Hospital
Rachel Oren - Yale University
Michael J. Higley - Yale University
Jessica A. Cardin - Yale University
Farzad Noubary - Northeastern University
Moritz Armbruster - Tufts University
Chris Dulla - Tufts University
Resource Type: Journal article
Publication Details: Cerebral cortex (New York, N.Y. 1991), Vol.34(2), 038
DOI: 10.1093/cercor/bhae038
PMID: 38365273
PMCID: PMC11486687
NLM abbreviation: Cereb Cortex
ISSN: 1047-3211
eISSN: 1460-2199
Publisher: Oxford Univ Press
Number of pages: 16
Grant note: PT0035 / American Epilepsy Society W81XWH1810699; W81XWH2210769 / U.S. Department of Defense; United States Department of Defense R21NS098009 / National Institute of Neurological Disease and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
Language: English
Date published: 01/31/2024
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984622751202771

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