Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

Cristina Contreras; Rubén Nogueiras; Carlos Diéguez; Kamal Rahmouni; Miguel López

doi:10.1016/j.redox.2017.04.019

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Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

Journal article

Open access

Peer reviewed

Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

Cristina Contreras, Rubén Nogueiras, Carlos Diéguez, Kamal Rahmouni and Miguel López

Redox biology, Vol.12, pp.854-863

08/2017

DOI: 10.1016/j.redox.2017.04.019

PMCID: PMC5406580

PMID: 28448947

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Abstract

Brown adipose tissue (BAT) is a specialized tissue critical for non-shivering thermogenesis producing heat through mitochondrial uncoupling; whereas white adipose tissue (WAT) is responsible of energy storage in the form of triglycerides. Another type of fat has been described, the beige adipose tissue; this tissue emerges in existing WAT depots but with thermogenic ability, a phenomenon known as browning. Several peripheral signals relaying information about energy status act in the brain, particularly the hypothalamus, to regulate thermogenesis in BAT and browning of WAT. Different hypothalamic areas have the capacity to regulate the thermogenic process in brown and beige adipocytes through the sympathetic nervous system (SNS). This review discusses important concepts and discoveries about the central control of thermogenesis as a trip that starts in the hypothalamus, and taking the sympathetic roads to reach brown and beige fat to modulate thermogenic functions.

Hypothalamus - metabolism

Thermogenesis

Humans

Adipose Tissue, White - metabolism

Adipose Tissue, Brown - metabolism

Sympathetic Nervous System - metabolism

Adipose Tissue, Beige - metabolism

Details

Title: Subtitle: Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway
Creators: Cristina Contreras - Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain. Electronic address: cristina.contreras@usc.es
Rubén Nogueiras - Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain
Carlos Diéguez - Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain
Kamal Rahmouni - Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa 52242, USA
Miguel López - Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain. Electronic address: m.lopez@usc.es
Resource Type: Journal article
Publication Details: Redox biology, Vol.12, pp.854-863
DOI: 10.1016/j.redox.2017.04.019
PMID: 28448947
PMCID: PMC5406580
NLM abbreviation: Redox Biol
ISSN: 2213-2317
eISSN: 2213-2317
Publisher: Netherlands
Grant note: P01 HL084207 / NHLBI NIH HHS
Language: English
Date published: 08/2017
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040276402771

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