Journal article
Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair
Neurobiology of learning and memory, Vol.159, pp.46-51
03/2019
DOI: 10.1016/j.nlm.2018.07.003
PMCID: PMC6329659
PMID: 30017897
Abstract
•Trax is a versatile signaling protein that interacts with multiple partner proteins.•Together with translin, it forms a microRNA-degrading enzyme.•This RNase mediates rapid reversal of translational silencing underlying plasticity.•Trax also plays a key role in DNA repair by binding to and activating ATM.\nTranslin-associated protein X (TSNAX), also called trax, was first identified as a protein that interacts with translin. Subsequent studies demonstrated that these proteins form a heteromeric RNase complex that mediates degradation of microRNAs, a pivotal finding that has stimulated interest in understanding the role of translin and trax in cell signaling. Recent studies addressing this question have revealed that trax plays key roles in both synaptic plasticity and DNA repair signaling pathways. In the context of synaptic plasticity, trax works together with its partner protein, translin, to degrade a subset of microRNAs. Activation of the translin/trax RNase complex reverses microRNA-mediated translational silencing to trigger dendritic protein synthesis critical for synaptic plasticity. In the context of DNA repair, trax binds to and activates ATM, a central component of the double-stranded DNA repair process. Thus, these studies focus attention on trax as a critical signaling protein that interacts with multiple partners to impact diverse signaling pathways. To stimulate interest in deciphering the multifaceted role of trax in cell signaling, we summarize the current understanding of trax biology and highlight gaps in our knowledge about this protean protein.
Details
- Title: Subtitle
- Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair
- Creators
- Yijuang Chern - Institute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanTing Chien - Institute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanXiuping Fu - Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United StatesAparna P Shah - Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United StatesTed Abel - Iowa Neuroscience Institute and Departments of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, United StatesJay M Baraban - Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States
- Resource Type
- Journal article
- Publication Details
- Neurobiology of learning and memory, Vol.159, pp.46-51
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.nlm.2018.07.003
- PMID
- 30017897
- PMCID
- PMC6329659
- ISSN
- 1074-7427
- eISSN
- 1095-9564
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: MH087463
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070893802771
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