Treatment Strategies for Therapy-related Acute Myeloid Leukemia

Prajwal Dhakal; Bimatshu Pyakuryal; Prasun Pudasainee; Venkat Rajasurya; Krishna Gundabolu; Vijaya Raj Bhatt

doi:10.1016/j.clml.2019.12.007

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Treatment Strategies for Therapy-related Acute Myeloid Leukemia

Journal article

Open access

Peer reviewed

Treatment Strategies for Therapy-related Acute Myeloid Leukemia

Prajwal Dhakal, Bimatshu Pyakuryal, Prasun Pudasainee, Venkat Rajasurya, Krishna Gundabolu and Vijaya Raj Bhatt

Clinical lymphoma, myeloma and leukemia, Vol.20(3), pp.147-155

03/2020

DOI: 10.1016/j.clml.2019.12.007

PMCID: PMC9302428

PMID: 31953046

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https://www.ncbi.nlm.nih.gov/pmc/articles/9302428View

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Abstract

Prospective evidence for management of therapy-related acute myeloid leukemia (t-AML) is limited, with evidence extrapolated from major AML trials. Optimal treatment is challenging and needs consideration of patient-specific, disease-specific, and therapy-specific factors. Clinical trials are recommended, especially for unfit patients or those with unfavorable cytogenetics or mutations. CPX-351 as an upfront intensive chemotherapy is preferred for fit patients; venetoclax with decitabine or azacitidine is an option for patients unfit for intensive chemotherapy. Hematopoietic cell transplant, the only curative option, should be offered to eligible patients with intermediate or unfavorable t-AML or patients with good-risk AML with minimal residual disease. Ongoing clinical trials focusing on treatment of t-AML, including targeted agents and immunotherapy, bode well for the future.

CPX-351

Hematopoietic cell transplant

t-AML

Unfavorable

Venetoclax

Details

Title: Subtitle: Treatment Strategies for Therapy-related Acute Myeloid Leukemia
Creators: Prajwal Dhakal - University of Nebraska Medical Center
Bimatshu Pyakuryal - Nepal Medical College Teaching Hospital
Prasun Pudasainee - Nepal Medical College Teaching Hospital
Venkat Rajasurya - Salem Chest Specialists, Winston Salem, NC
Krishna Gundabolu - University of Nebraska Medical Center
Vijaya Raj Bhatt - University of Nebraska Medical Center
Resource Type: Journal article
Publication Details: Clinical lymphoma, myeloma and leukemia, Vol.20(3), pp.147-155
DOI: 10.1016/j.clml.2019.12.007
PMID: 31953046
PMCID: PMC9302428
NLM abbreviation: Clin Lymphoma Myeloma Leuk
ISSN: 2152-2650
eISSN: 2152-2669
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000057, name: National Institute of General Medical Sciences
Language: English
Date published: 03/2020
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984359872602771

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