Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer From 1988 to 2012

Sobia F Khaja; Henry T Hoffman; Nitin A Pagedar

doi:10.1177/0003489415611908

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Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer From 1988 to 2012

Journal article

Peer reviewed

Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer From 1988 to 2012

Sobia F Khaja, Henry T Hoffman and Nitin A Pagedar

Annals of otology, rhinology & laryngology, Vol.125(4), pp.311-316

04/2016

DOI: 10.1177/0003489415611908

PMID: 26481178

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Abstract

To identify trends in treatment and survival for patients with stage I glottic cancer and glottic carcinoma in situ (CIS). The 18-registry SEER data were analyzed for CIS and stage I glottic cancer. Treatment variables and observed and relative survival were assessed separately for stage I and glottic CIS. Among 14 025 cases of stage I glottic cancer identified from 1988 to 2012, radiation was the most common treatment for all eras. An increase in surgical treatment occurred with a decline in combination therapy. There were 3169 cases of glottic CIS, with surgery the most common initial treatment but with radiotherapy increasing across the years. Relative survival was similar for treatment type and era of diagnosis. Among the 3738 patients with glottic CIS, 5.4% went on to develop invasive glottic carcinoma of any stage, with invasive cancer more common in patients treated by surgery alone compared to radiation or surgery with radiation. Despite changes in treatment modalities for CIS and stage I glottic cancer, there have not been significant changes in survival for CIS, with slightly improved survival for treatment with surgery alone. Patients treated with surgery alone had an increased rate of subsequent invasive cancer.

United States

Carcinoma, Squamous Cell - pathology

Humans

Radiotherapy, Adjuvant - trends

Laryngeal Neoplasms - pathology

Laryngeal Neoplasms - therapy

Squamous Cell Carcinoma of Head and Neck

Carcinoma, Squamous Cell - mortality

Registries

Retrospective Studies

SEER Program

Survival Rate - trends

Carcinoma in Situ - pathology

Head and Neck Neoplasms - therapy

Kaplan-Meier Estimate

Carcinoma, Squamous Cell - therapy

Carcinoma in Situ - therapy

Radiotherapy - trends

Head and Neck Neoplasms - pathology

Laryngectomy - trends

Laryngeal Neoplasms - mortality

Head and Neck Neoplasms - mortality

Neoplasm Staging

Carcinoma in Situ - mortality

Glottis - pathology

Details

Title: Subtitle: Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer From 1988 to 2012
Creators: Sobia F Khaja - Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
Henry T Hoffman - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA
Nitin A Pagedar - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA nitin-pagedar@uiowa.edu
Resource Type: Journal article
Publication Details: Annals of otology, rhinology & laryngology, Vol.125(4), pp.311-316
Publisher: United States
DOI: 10.1177/0003489415611908
PMID: 26481178
ISSN: 0003-4894
eISSN: 1943-572X
Grant note: DP2 OD007483 / NIH HHS P30 CA086862 / NCI NIH HHS
Language: English
Date published: 04/2016
Academic Unit: Radiation Oncology; Otolaryngology
Record Identifier: 9984006494202771

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