Journal article
Treatment and survival in 10,429 patients with localized laryngeal cancer: A population-based analysis
Cancer, Vol.120(12), pp.1810-1817
06/15/2014
DOI: 10.1002/cncr.28608
PMCID: PMC5560918
PMID: 24639148
Abstract
BACKGROUND
The objectives of this study were to identify factors associated with treatment differences, characterize changes in treatment patterns over time, and compare survival across treatment types in patients who received treatment for localized laryngeal cancer.
METHODS
Using the Surveillance, Epidemiology, and End Results database, we conducted a retrospective cohort analysis of patients who were treated from 1995 to 2009 for localized laryngeal cancer. Four treatment groups were defined: (1) radiation only, (2) local surgery only, (3) local surgery and radiation, and (4) open surgery with or without radiation. Variations in treatment rates between these groups were evaluated according to demographic factors, and differences in treatment rates across time were calculated. Associations between treatment and mortality were assessed using Kaplan-Meier methods. Cox proportional hazards regression models were used to adjust for potential confounding covariates.
RESULTS
In total, 10,429 patients with localized laryngeal cancer were identified. Most patients (57%) were treated with radiation only; 25% with local surgery and radiation, 9% with local surgery only, and 9% with open surgery with or without radiation. Race, age, and registry were associated with differences in treatment. Receipt of single-modality treatment increased and receipt of combined-modality treatment decreased over the study period. Better survival was observed with white race, younger age, and treatment with local surgery. Survival differences associated with treatment type were observed within 3 years of diagnosis and persisted beyond 5 years after diagnosis.
CONCLUSIONS
Although treatment patterns became more adherent to treatment guidelines over time, we identified survival differences associated with treatment type that warrant further investigation into treatment decision-making for patients with localized laryngeal cancer.
Details
- Title: Subtitle
- Treatment and survival in 10,429 patients with localized laryngeal cancer: A population-based analysis
- Creators
- Stephanie Misono - University of MinnesotaSchelomo Marmor - University of MinnesotaBevan Yueh - University of MinnesotaBeth A. Virnig - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Cancer, Vol.120(12), pp.1810-1817
- DOI
- 10.1002/cncr.28608
- PMID
- 24639148
- PMCID
- PMC5560918
- NLM abbreviation
- Cancer
- ISSN
- 0008-543X
- eISSN
- 1097-0142
- Number of pages
- 8
- Grant note
- UL1TR000114 / National Center for Advancing Translational Sciences (http://data.elsevier.com/vocabulary/SciValFunders/100006108)
- Language
- English
- Date published
- 06/15/2014
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984966749402771
Metrics
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