Journal article
Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States
American journal of transplantation, Vol.18(1), pp.245-252
01/2018
DOI: 10.1111/ajt.14530
PMCID: PMC5739985
PMID: 28980390
Abstract
Recent case series describe detection of BK polyomavirus (BKV) in urinary tract cancers in kidney transplant recipients, suggesting that BKV could contribute to the development of these cancers. We assessed risk for urinary tract cancers in kidney recipients with or without treatment for presumed BKV nephropathy (tBKVN) using data from the United States Transplant Cancer Match Study (2003-2013). Among 55 697 included recipients, 2015 (3.6%) were reported with tBKVN. Relative to the general population, incidence was similarly elevated (approximately 4.5-fold) for kidney cancer in recipients with or without tBKVN, and incidence was not increased in either group for prostate cancer. In contrast, for invasive bladder cancer, incidence was more strongly elevated in recipients with versus without tBKVN (standardized incidence ratios 4.5 vs. 1.7; N = 48 cases), corresponding to an incidence rate ratio (IRR) of 2.9 (95% confidence interval [CI] 1.0-8.2), adjusted for sex, age, transplant year, and use of polyclonal antibody induction. As a result, recipients with tBKVN had borderline increased incidence for all urothelial cancers combined (renal pelvis, ureter, and bladder cancers: adjusted IRR 2.2, 95% CI 0.9-5.4; N = 89 cases). Together with reports describing BKV detection in tumor tissues, these results support an association between BKV and urothelial carcinogenesis among kidney transplant recipients.
Details
- Title: Subtitle
- Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States
- Creators
- Gaurav Gupta - Virginia Commonwealth University, Richmond, VA, USASarat Kuppachi - University of Iowa, Iowa City, IA, USARoberto S Kalil - University of Iowa, Iowa City, IA, USAChristopher B Buck - National Cancer Institute, Bethesda, MD, USACharles F Lynch - University of Iowa, Iowa City, IA, USAEric A Engels - National Cancer Institute, Bethesda, MD, USA
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.18(1), pp.245-252
- Publisher
- United States
- DOI
- 10.1111/ajt.14530
- PMID
- 28980390
- PMCID
- PMC5739985
- ISSN
- 1600-6143
- eISSN
- 1600-6143
- Grant note
- N01PC35142 / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS U58 DP003875 / NCCDPHP CDC HHS Z01 CP010150-09 / Intramural NIH HHS U58 DP003931 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS U58 DP003921 / NCCDPHP CDC HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS U58 DP003879 / NCCDPHP CDC HHS HHSN261201300011C / CCR NIH HHS HHSN261201300071C / NCI NIH HHS U58 DP003920 / NCCDPHP CDC HHS U58 DP000848 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS HHSN261201300021C / NCI NIH HHS HHSN261201300011I / NCI NIH HHS HHSN261201000037C / NCI NIH HHS N01PC35143 / NCI NIH HHS HHSN261201300019C / NCI NIH HHS U58 DP003883 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Internal Medicine
- Record Identifier
- 9983996189102771
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