Journal article
Treatment of Helicobacter pylori Gastritis Improves Dyspeptic Symptoms in Children
Journal of pediatric gastroenterology and nutrition, Vol.34(3), pp.281-285
03/2002
DOI: 10.1097/00005176-200203000-00010
PMID: 11964952
Abstract
BACKGROUNDIn adults, the treatment of Helicobacter pylori infection is only recommended for patients with active gastric or duodenal ulcers. It is not known whether similar guidelines can be applied to children because the prevalence of peptic ulcer disease in childhood is estimated to be much lower than in adults. The purpose of this study was to determine whether treatment of H. pylori gastritis would improve symptoms of dyspepsia in children.
METHODSSixteen patients (5 boys, 11 girls) aged 14 ± 1.2 years who had symptoms of dyspepsia were evaluated using upper gastrointestinal endoscopy with biopsies to establish the diagnosis of H. pylori gastritis. They were treated for 2 weeks with clarithromycin, amoxicillin, and a proton pump inhibitor. Dyspepsia symptoms were evaluated by a questionnaire before and after treatment of the infection. The effect of H. pylori treatment on the total symptom score was analyzed with use of the Student t test. Values are presented as mean ± SEM.
RESULTSAll patients had antral nodularity and chronic active gastritis with spiral-shaped organisms but no evidence of peptic ulcer disease. Mean total symptom score decreased significantly at 2 to 4 weeks after treatment (12.6 ± 0.9 vs. 2.1 ± 0.5 P < 0.001), and it remained low (2.9 ± 0.7) at follow-up 9.7 ± 1.4 months (range, 2–24 months later).
CONCLUSIONThese results suggest that the treatment of H. pylori gastritis can improve dyspeptic symptoms in children.
Details
- Title: Subtitle
- Treatment of Helicobacter pylori Gastritis Improves Dyspeptic Symptoms in Children
- Creators
- Aliye Uc - St. Bernards Clopton ClinicSonny Chong
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric gastroenterology and nutrition, Vol.34(3), pp.281-285
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00005176-200203000-00010
- PMID
- 11964952
- ISSN
- 0277-2116
- eISSN
- 1536-4801
- Language
- English
- Date published
- 03/2002
- Academic Unit
- Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984313083302771
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