Journal article
Treatment of Intractable Lupus Nephritis with Total Lymphoid Irradiation
Annals of internal medicine, Vol.102(4), p.450
04/01/1985
DOI: 10.1059/0003-4819-102-4-450
PMID: 3872090
Abstract
Ten patients with lupus nephritis and marked proteinuria (3.9 g or more /d) that did not respond adequately to treatment with
prednisone alone or prednisone in combination with azathioprine were treated with total lymphoid irradiation in an uncontrolled
feasibility study. Within 6 weeks after the start of total lymphoid irradiation, the serum albumin level rose in all patients
in association with a reduction in the serum level of anti-DNA antibodies, an increase in the serum complement level, or both.
Improvement in these variables persisted in eight patients followed for more than 1 year, with the stabilization or reduction
of the serum creatinine level. Urinary leakage of albumin was substantially reduced in all patients. Side effects associated
with radiotherapy included transient constitutional complaints in ten patients, transient blood element depressions in three,
localized viral and bacterial infections in four, and ovarian failure in one. The results suggest that total lymphoid irradiation
may provide an alternative to cytotoxic drugs in the treatment of lupus nephritis.
Details
- Title: Subtitle
- Treatment of Intractable Lupus Nephritis with Total Lymphoid Irradiation
- Creators
- SAMUEL STROBERELIZABETH FIELD - University of Iowa, Internal MedicineRICHARD T. HOPPEBRIAN L. KOTZINOVADIA SHEMESHEDGAR ENGLEMANJON C. ROSSBRYAN D. MYERS
- Resource Type
- Journal article
- Publication Details
- Annals of internal medicine, Vol.102(4), p.450
- Publisher
- American College of Physicians
- DOI
- 10.1059/0003-4819-102-4-450
- PMID
- 3872090
- ISSN
- 0003-4819
- eISSN
- 1539-3704
- Language
- English
- Date published
- 04/01/1985
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094873402771
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