Journal article
Treatment of Lymphangiomas in Children: An Update of Picibanil (OK-432) Sclerotherapy
Otolaryngology--head and neck surgery, Vol.121(4), pp.381-387
10/1999
DOI: 10.1016/S0194-5998(99)70225-1
PMID: 10504592
Abstract
Picibanil (OK-432) is a sclerosing agent derived from a low-virulence strain of Streptococcus pyogenes that induces regression of macrocystic lymphangiomas. This report describes a prospective, nonrandomized trial to evaluate the efficacy of Picibanil in the treatment of 13 affected children ranging in age from 1 to 94 months. On average, 4.1 fluoroscopically guided intracystic injections were performed per child, with an average total dose of 0.56 mg of Picibanil. As judged by physical examination and radiographic studies, 5 children (42%) showed a complete or substantial response, and 2 children (16%) showed an intermediate response. No response was seen in 5 children (42%), 2 of whom had massive craniofacial lymphangioma. Factors that contribute to failure with Picibanil sclerotherapy are the presence of a significant micro-cystic component to the lesion, massive craniofacial involvement, and previous surgical resection. Macrocystic lymphangiomas of the infratemporal fossa or cervical area have the best response to therapy.
Details
- Title: Subtitle
- Treatment of Lymphangiomas in Children: An Update of Picibanil (OK-432) Sclerotherapy
- Creators
- John H Greinwald - Iowa City, Iowa, Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery. University of IowaDiane K Burke - Iowa City, Iowa, Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery. University of IowaYukato Sato - Iowa City, Iowa, Department of Radiology, University of IowaRolland I Poust - Iowa City, Iowa, College of Pharmacy, University of IowaKen Kimura - Iowa City, Iowa, Department of SurgeryNancy M Bauman - Iowa City, Iowa, Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery. University of IowaRichard J. H Smith - Iowa City, Iowa, Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery. University of Iowa
- Resource Type
- Journal article
- Publication Details
- Otolaryngology--head and neck surgery, Vol.121(4), pp.381-387
- DOI
- 10.1016/S0194-5998(99)70225-1
- PMID
- 10504592
- NLM abbreviation
- Otolaryngol Head Neck Surg
- ISSN
- 0194-5998
- eISSN
- 1097-6817
- Language
- English
- Date published
- 10/1999
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pharmacy; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Surgery; Otolaryngology; Internal Medicine
- Record Identifier
- 9984007185602771
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