Journal article
Treatment of Pediatric Migraine
The New England journal of medicine, Vol.376(14), pp.1387-1389
04/06/2017
DOI: 10.1056/NEJMc1701674
PMCID: PMC5495100
PMID: 28382806
Abstract
To the Editor:
Powers and colleagues (Jan. 12 issue)
1
report the results of a randomized, double-blind, placebo-controlled trial investigating the efficacy of amitriptyline and topiramate versus placebo as potential preventive treatments in children and adolescents with migraine. Placebo that was administered for 24 weeks was associated with a clinically significant 61% reduction from baseline in the incidence of migraine, which was larger than the reductions from baseline that were observed with amitriptyline (52%) and topiramate (55%), a finding that brings attention to the placebo response.
2
However, caution is needed in interpreting the reduction in the placebo group.
3
Placebo effects are . . .
Details
- Title: Subtitle
- Treatment of Pediatric Migraine
- Creators
- Luana Colloca - University of Maryland, Baltimore, MDRobert D Mauro - University of Colorado School of Medicine, Aurora, COScott W Powers - Cincinnati Children’s Hospital Medical Center, Cincinnati, OHChristopher S Coffey - University of Iowa, Iowa City, IAAndrew D Hershey - Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.376(14), pp.1387-1389
- DOI
- 10.1056/NEJMc1701674
- PMID
- 28382806
- PMCID
- PMC5495100
- NLM abbreviation
- N Engl J Med
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Publisher
- Massachusetts Medical Society
- Language
- English
- Date published
- 04/06/2017
- Academic Unit
- Biostatistics
- Record Identifier
- 9984214706002771
Metrics
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