Journal article
Treatment of Streptozotocin-Induced Diabetic Rats with Alogliptin: Effect on Vascular and Neural Complications
Experimental diabetes research, Vol.2011, pp.1-7
2011
DOI: 10.1155/2011/810469
PMCID: PMC3142682
PMID: 21822422
Abstract
We sought to determine the effect of dipeptidyl peptidase IV (DPP-IV) inhibition on streptozotocin diabetes-induced vascular and neural dysfunction. After 4 weeks of untreated diabetes, rats were treated for 12 weeks with Alogliptin (DPP-IV inhibitor). Diabetes caused a slowing of motor and sensory nerve conduction velocity, thermal hypoalgesia, reduction in intraepidermal nerve fiber density in the hindpaw, and impairment in vascular relaxation to acetylcholine and calcitonin gene-related peptide in epineurial arterioles. Treatment significantly improved motor nerve conduction velocity and thermal response latency. Sensory nerve conduction velocity was marginally improved with treatment of diabetic rats, and treatment did not improve the decrease in intraepidermal nerve fiber density. Vascular relaxation by epineurial arterioles to calcitonin gene-related peptide but not acetylcholine was significantly improved with treatment. These studies suggest that some but not all vascular and neural complications associated with type 1 diabetes can be improved with the inhibition of DPP-IV activity.
Details
- Title: Subtitle
- Treatment of Streptozotocin-Induced Diabetic Rats with Alogliptin: Effect on Vascular and Neural Complications
- Creators
- Eric P Davidson - Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USALawrence J Coppey - Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USABrian Dake - Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USAMark A Yorek - Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA, Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA 52246, USA
- Resource Type
- Journal article
- Publication Details
- Experimental diabetes research, Vol.2011, pp.1-7
- DOI
- 10.1155/2011/810469
- PMID
- 21822422
- PMCID
- PMC3142682
- NLM abbreviation
- Exp Diabetes Res
- ISSN
- 1687-5214
- eISSN
- 1687-5303
- Grant note
- DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: DK073990
- Language
- English
- Date published
- 2011
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094733502771
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