Journal article
Treatment of acanthamoeba keratitis with intravenous pentamidine before therapeutic keratoplasty
Cornea, Vol.34(1), pp.49-53
01/2015
DOI: 10.1097/ICO.0000000000000263
PMID: 25255139
Abstract
The aim of this study was to evaluate the outcome of pretreatment of Acanthamoeba keratitis with intravenous pentamidine (IVP) before therapeutic keratoplasty (TKP). A retrospective chart review was performed of the medical records of every patient treated with IVP before TKP for Acanthamoeba keratitis at a single, tertiary care eye center between January 1, 2002, and December 31, 2012. The main outcome measures were microbiological cure, graft survival, and visual outcome. Eight eyes of 7 patients met the inclusion criteria. Preoperatively, all 8 eyes had failed traditional antiamoebic therapy, including 5 eyes with recurrent infections after previous TKP. The patients were treated with IVP (190-400 mg/d) for a median of 14 days (range, 7-26 days). After 8 TKP, a microbiological cure was achieved, and a clear graft was maintained in 5 (62.5%) eyes during a mean follow-up interval of 31.2 months (range, 1.0-95.7 months). Repeat TKP in 3 eyes with recurrent Acanthamoeba keratitis resulted in 2 additional microbiological cures and 1 more clear graft. The final best-corrected visual acuity was ≥20/40 in 5 (62.5%) eyes and worse than 20/200 in 3 eyes. Overall, the final vision was improved in 6 (75.0%) eyes, remained the same in 1 (12.5%) eye, and was worse in 1 (12.5%) eye. The adjunctive use of IVP before TKP may assist with the achievement of microbiological cure, clear graft, and good visual outcome in a majority of eyes with Acanthamoeba keratitis.
Details
- Title: Subtitle
- Treatment of acanthamoeba keratitis with intravenous pentamidine before therapeutic keratoplasty
- Creators
- Bradley A Sacher - Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA; and †Department of Ophthalmology, Kansas University Medical Center, Kansas City, KSMichael D WagonerKenneth M GoinsJohn E SutphinMark A GreinerAnna S Kitzmann
- Resource Type
- Journal article
- Publication Details
- Cornea, Vol.34(1), pp.49-53
- Publisher
- United States
- DOI
- 10.1097/ICO.0000000000000263
- PMID
- 25255139
- ISSN
- 0277-3740
- eISSN
- 1536-4798
- Language
- English
- Date published
- 01/2015
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983980047502771
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