Journal article
Treatment of hospitalized patients with complicated skin and skin structure infections : double-blind, randomized, multicenter study of piperacillin-tazobactam versus ticarcillin-clavulanate
Antimicrobial agents and chemotherapy, Vol.37(8), pp.1580-1586
1993
DOI: 10.1128/AAC.37.8.1580
PMCID: PMC188023
PMID: 8215266
Abstract
We compared the efficacy and safety of two β-lactam-β-lactamase inhibitor combinations, namely, piperacillin-tazobactam and ticarcillin- clavulanate, in the treatment of complicated bacterial infections of skin that required hospitalization. The study was a randomized, double-blind, comparative trial involving 20 centers. The infections were classified as (i) cellulitis with drainage, (ii) cutaneous abscess, (iii) diabetic or ischemic foot infection, and (iv) infected wounds and ulcers with drainage. The clinical response rates were comparable for the two treatment regimens (61% of the patients were cured with piperacillin-tazobactam and ticarcillin- clavulanate and improvement was seen in 15 and 16% of patients treated with piperacillin-tazobactam and ticarcillin-clavulanate, respectively). Both regimens were found to be safe and well tolerated. These data support the use of piperacillin-tazobactam for initial empiric therapy of hospitalized patients with complicated skin and skin structure infections.
Details
- Title: Subtitle
- Treatment of hospitalized patients with complicated skin and skin structure infections : double-blind, randomized, multicenter study of piperacillin-tazobactam versus ticarcillin-clavulanate
- Creators
- J. S Tan - Ohio UniversityR. M Wishnow - Ohio UniversityD. A Talan - Ohio UniversityF. P Duncanson - Ohio UniversityC. W Norden - Ohio University
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.37(8), pp.1580-1586
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/AAC.37.8.1580
- PMID
- 8215266
- PMCID
- PMC188023
- ISSN
- 0066-4804
- eISSN
- 1098-6596
- Language
- English
- Date published
- 1993
- Academic Unit
- Emergency Medicine; Internal Medicine
- Record Identifier
- 9984296978502771
Metrics
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