Journal article
Treatment of lupus nephritis with total lymphoid irradiation. observations during a 12–79-month followup
Arthritis and rheumatism, Vol.31(7), pp.850-858
07/1988
DOI: 10.1002/art.1780310705
PMID: 3260782
Abstract
Seventeen patients with intractable lupus nephritis and nephrotic syndrome were treated with total lymphoid irradiation. Statistically significant improvement in mean renal disease and serologic activity parameters occurred within 3 months and persisted for at least 3 years. Although there was a marked reduction of T helper cell numbers and function after total lymphoid irradiation, recovery of these parameters was not associated with a return of disease activity. Risks of sterility, severe infections, and hematologic malignancy appeared to be lower than with alkylating agents.
Details
- Title: Subtitle
- Treatment of lupus nephritis with total lymphoid irradiation. observations during a 12–79-month followup
- Creators
- Samuel StroberM. Carmen FariñasElizabeth H FieldJose J SoloveraBryce A KiberdBryan D MyersRichard T Hoppe
- Resource Type
- Journal article
- Publication Details
- Arthritis and rheumatism, Vol.31(7), pp.850-858
- DOI
- 10.1002/art.1780310705
- PMID
- 3260782
- NLM abbreviation
- Arthritis Rheum
- ISSN
- 0004-3591
- eISSN
- 1529-0131
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- NIADDK (AM‐33340) Foundation of Marques de Valdecilla
- Language
- English
- Date published
- 07/1988
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094591502771
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