Treatment of newly diagnosed severe aplastic anemia in children: Evidence-based recommendations

Kristin A Shimano; Jennifer A Rothman; Steven W Allen; Paul Castillo; Jill L O de Jong; Yigal Dror; Amy E Geddis; Bonnie W Lau; Catherine McGuinn; Anupama Narla; Kathleen Overholt; Maria A Pereda; Anjali Sharathkumar; Ghadir Sasa; Taizo A Nakano; Kasiani Myers; Nicholas J Gloude; Larisa Broglie; Jessica Boklan

doi:10.1002/pbc.31070

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Treatment of newly diagnosed severe aplastic anemia in children: Evidence-based recommendations

Journal article

Open access

Peer reviewed

Treatment of newly diagnosed severe aplastic anemia in children: Evidence-based recommendations

Kristin A Shimano, Jennifer A Rothman, Steven W Allen, Paul Castillo, Jill L O de Jong, Yigal Dror, Amy E Geddis, Bonnie W Lau, Catherine McGuinn, Anupama Narla, …

Pediatric blood & cancer, Vol.71(8), e31070

08/2024

DOI: 10.1002/pbc.31070

PMID: 38757488

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Abstract

Severe aplastic anemia (SAA) is a rare potentially fatal hematologic disorder. Although overall outcomes with treatment are excellent, there are variations in management approach, including differences in treatment between adult and pediatric patients. Certain aspects of treatment are under active investigation in clinical trials. Because of the rarity of the disease, some pediatric hematologists may have relatively limited experience with the complex management of SAA. The following recommendations reflect an up-to-date evidence-based approach to the treatment of children with newly diagnosed SAA.

bone marrow failure

aplastic anemia

pediatric hematology/oncology

Details

Title: Subtitle: Treatment of newly diagnosed severe aplastic anemia in children: Evidence-based recommendations
Creators: Kristin A Shimano - UCSF Benioff Children's Hospital
Jennifer A Rothman - Duke Medical Center
Steven W Allen - Children's Hospital of Pittsburgh
Paul Castillo - UF Health Shands Hospital
Jill L O de Jong - University of Chicago
Yigal Dror - Hospital for Sick Children
Amy E Geddis - Seattle Children's Hospital
Bonnie W Lau - Dartmouth–Hitchcock Medical Center
Catherine McGuinn - Cornell University
Anupama Narla - Stanford University
Kathleen Overholt - Riley Hospital for Children
Maria A Pereda - Center for Cancer and Blood Disorders
Anjali Sharathkumar - University of Iowa
Ghadir Sasa - Sarah Cannon
Taizo A Nakano - Center for Cancer and Blood Disorders
Kasiani Myers - Cincinnati Children's Hospital Medical Center
Nicholas J Gloude - Rady Children's Hospital-San Diego
Larisa Broglie - Medical College of Wisconsin
Jessica Boklan - Center for Cancer and Blood Disorders
Resource Type: Journal article
Publication Details: Pediatric blood & cancer, Vol.71(8), e31070
DOI: 10.1002/pbc.31070
PMID: 38757488
NLM abbreviation: Pediatr Blood Cancer
eISSN: 1545-5017
Language: English
Electronic publication date: 05/16/2024
Date published: 08/2024
Academic Unit: Stead Family Department of Pediatrics; Hematology/Oncology
Record Identifier: 9984628215802771

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