Treatment of relapsed/refractory severe aplastic anemia in children: Evidence-based recommendations

Kristin A Shimano; Ghadir Sasa; Larisa Broglie; Nicholas J Gloude; Kasiani Myers; Taizo A Nakano; Anjali Sharathkumar; Jennifer A Rothman; Maria A Pereda; Kathleen Overholt; Anupama Narla; Catherine McGuinn; Bonnie W Lau; Amy E Geddis; Yigal Dror; Jill L O de Jong; Paul Castillo; Steven W Allen; Jessica Boklan

doi:10.1002/pbc.31075

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$Treatment of relapsed/refractory severe aplastic anemia in children: Evidence-based recommendations$

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Treatment of relapsed/refractory severe aplastic anemia in children: Evidence-based recommendations

Kristin A Shimano, Ghadir Sasa, Larisa Broglie, Nicholas J Gloude, Kasiani Myers, Taizo A Nakano, Anjali Sharathkumar, Jennifer A Rothman, Maria A Pereda, Kathleen Overholt, …

Pediatric blood & cancer, Vol.71(8), e31075

08/2024

DOI: 10.1002/pbc.31075

PMID: 38764170

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Abstract

Severe aplastic anemia (SAA) is a rare potentially fatal hematologic disorder. Although overall outcomes with treatment are excellent, there are variations in management approach, including differences in treatment between adult and pediatric patients. Certain aspects of treatment are under active investigation in clinical trials. Because of the rarity of the disease, some pediatric hematologists may have relatively limited experience with the complex management of SAA. The following recommendations reflect an up-to-date evidence-based approach to the treatment of children with relapsed or refractory SAA.

bone marrow failure

aplastic anemia

pediatric hematology/oncology

Details

Title: Subtitle: Treatment of relapsed/refractory severe aplastic anemia in children: Evidence-based recommendations
Creators: Kristin A Shimano - UCSF Benioff Children's Hospital
Ghadir Sasa - Sarah Cannon
Larisa Broglie - Medical College of Wisconsin
Nicholas J Gloude - Rady Children's Hospital-San Diego
Kasiani Myers - Cincinnati Children's Hospital Medical Center
Taizo A Nakano - Center for Cancer and Blood Disorders
Anjali Sharathkumar - University of Iowa
Jennifer A Rothman - Duke Medical Center
Maria A Pereda - Center for Cancer and Blood Disorders
Kathleen Overholt - Riley Hospital for Children
Anupama Narla - Stanford University
Catherine McGuinn - Weill Cornell Medicine
Bonnie W Lau - Dartmouth–Hitchcock Medical Center
Amy E Geddis - Seattle Children's Hospital
Yigal Dror - Hospital for Sick Children
Jill L O de Jong - University of Chicago
Paul Castillo - UF Health Shands Hospital
Steven W Allen - Children's Hospital of Pittsburgh
Jessica Boklan - Center for Cancer and Blood Disorders
Resource Type: Journal article
Publication Details: Pediatric blood & cancer, Vol.71(8), e31075
DOI: 10.1002/pbc.31075
PMID: 38764170
NLM abbreviation: Pediatr Blood Cancer
eISSN: 1545-5017
Publisher: Wiley
Language: English
Electronic publication date: 05/19/2024
Date published: 08/2024
Academic Unit: Stead Family Department of Pediatrics; Hematology/Oncology
Record Identifier: 9984628216802771

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