Journal article
Treatment of urethral stricture disease in women: A multi‐institutional collaborative project from the SUFU research network
Neurourology and urodynamics, Vol.39(8), pp.2433-2441
11/2020
DOI: 10.1002/nau.24507
PMID: 32926460
Abstract
Aim: Female urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or urethroplasty with free graft (UFG). This study aims to describe the contemporary management of female urethral stricture disease and to evaluate the outcomes of these three surgical approaches. Methods: This is a multi-institutional, retrospective cohort study evaluating operative treatment for female urethral stricture. Surgeries were grouped into three categories: ENDO, ULT, and UFG. Time from surgery to stricture recurrence by surgery type was analyzed using a Kaplan–Meier time to event analysis. To adjust for confounders, a Cox proportional hazard model was fit for time to stricture recurrence. Results: Two-hundred and ten patients met the inclusion criteria across 23 sites. Overall, 64% (n = 115/180) of women remained recurrence free at median follow-up of 14.6 months (IQR, 3–37). In unadjusted analysis, recurrence-free rates differed between surgery categories with 68% ENDO, 77% UFG and 83% ULT patients being recurrence free at 12 months. In the Cox model, recurrence rates also differed between surgery categories; women undergoing ULT and UFG having had 66% and 49% less risk of recurrence, respectively, compared to those undergoing ENDO. When comparing ULT to UFG directly, there was no significant difference of recurrence. Conclusion: This retrospective multi-institutional study of female urethral stricture demonstrates that patients undergoing endoscopic management have a higher risk of recurrence compared to those undergoing either urethroplasty with local flap or free graft.
Details
- Title: Subtitle
- Treatment of urethral stricture disease in women: A multi‐institutional collaborative project from the SUFU research network
- Creators
- Giulia I. Lane - University of Michigan–Ann ArborAriana L. Smith - University of PennsylvaniaHanna Stambakio - University of PennsylvaniaGeorge Lin - University of PennsylvaniaOmar Al Hussein Alawamlh - Weill Cornell MedicineJennifer T. Anger - Cedars-Sinai Medical CenterEileen R. Brandes - Dartmouth–Hitchcock Medical CenterMaude E. Carmel - The University of Texas Southwestern Medical CenterDoreen E. Chung - Columbia UniversityLindsey Cox - Medical University of South CarolinaJessica DeLong - Eastern Virginia Medical SchoolChristopher S. Elliott - Santa Clara Valley Medical CenterEhab Eltahawy - University of Arkansas for Medical SciencesWagner Aparecido França - Hospital do Servidor Público EstadualAngelo Gousse - Department of Urology Memorial Hospital Miramar Miramar Florida USAPriyanka Gupta - University of Michigan–Ann ArborJudith C. Hagedorn - University of WashingtonRachel A. High - Scott & White HospitalAqsa Khan - Mayo Clinic in ArizonaCasey Kowalik - Department of Urology Kansas University Medical Center Kansas City Kansas USARichard K. Lee - Weill Cornell MedicineUna J. Lee - Virginia Mason Medical CenterAlvaro Lucioni - Virginia Mason Medical CenterSusan MacDonald - Penn State Milton S. Hershey Medical CenterBahaa Malaeb - University of Michigan–Ann ArborScotty McKay - University of Arkansas for Medical SciencesPriya Padmanabhan - Department of Urology, Beaumont Hospital, Royal Oak, Michigan, USA.Charles R. Powell - Indiana University IndianapolisKamran P. Sajadi - Oregon Health & Science UniversitySuzette E. Sutherland - University of WashingtonDidi Theva - Department of Urology Memorial Hospital Miramar Miramar Florida USAAnnah Vollstedt - University of PennsylvaniaBlayne Welk - Western UniversityYu Zheng - Medical University of South CarolinaAnne P. Cameron - University of Michigan–Ann ArborSociety of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Research Network (SURN)
- Resource Type
- Journal article
- Publication Details
- Neurourology and urodynamics, Vol.39(8), pp.2433-2441
- DOI
- 10.1002/nau.24507
- PMID
- 32926460
- ISSN
- 0733-2467
- eISSN
- 1520-6777
- Grant note
- DOI: 10.13039/100011240, name: Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Foundation; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1TR002240
- Language
- English
- Date published
- 11/2020
- Academic Unit
- Urology
- Record Identifier
- 9984320856502771
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