Journal article
Tremor supression following treatment with MRgFUS: skull density ratio consistency and degree of posterior dentatorubrothalamic tract lesioning predicts long-term clinical outcomes in essential tremor
Frontiers in neurology, Vol.14, 1129430
04/25/2023
DOI: 10.3389/fneur.2023.1129430
PMCID: PMC10166854
PMID: 37181561
Abstract
ObjectivesMagnetic resonance-guided focussed ultrasound (MRgFUS) is an incisionless ablative procedure, widely used for treatment of Parkinsonian and Essential Tremor (ET). Enhanced understanding of the patient- and treatment-specific factors that influence sustained long-term tremor suppression could help clinicians achieve superior outcomes via improved patient screening and treatment strategy. MethodsWe retrospectively analysed data from 31 subjects with ET, treated with MRgFUS at a single centre. Tremor severity was assessed with parts A, B and C of the Clinical Rating Scale for Tremor (CRST) as well as the combined CRST. Tremor in the dominant and non-dominant hand was assessed with Hand Tremor Scores (HTS), derived from the CRST. Pre- and post-treatment imaging data were analysed to determine ablation volume overlap with automated thalamic segmentations, and the dentatorubrothalamic tract (DRTT) and compared with percentage change in CRST and HTS following treatment. ResultsTremor symptoms were significantly reduced following treatment. Combined pre-treatment CRST (mean: 60.7 +/- 17.3) and HTS (mean: 19.2 +/- 5.7) improved by an average of 45.5 and 62.6%, respectively. Percentage change in CRST was found to be significantly negatively associated with age (beta = -0.375, p = 0.015), and SDR standard deviation (SDRSD; beta = -0.324, p = 0.006), and positively associated with ablation overlap with the posterior DRTT (beta = 0.535, p < 0.001). Percentage HTS improvement in the dominant hand decreased significantly with older age (beta = -0.576, p < 0.01). ConclusionOur results suggest that increased lesioning of the posterior region of the DRTT could result in greater improvements in combined CRST and non-dominant hand HTS, and that subjects with lower SDR standard deviation tended to experience greater improvement in combined CRST.
Details
- Title: Subtitle
- Tremor supression following treatment with MRgFUS: skull density ratio consistency and degree of posterior dentatorubrothalamic tract lesioning predicts long-term clinical outcomes in essential tremor
- Creators
- Kain Kyle - Cooperative Trials Group for Neuro-OncologyJerome Maller - GE Healthcare (Netherlands)Yael Barnett - St Vincent's Hospital SydneyBenjamin Jonker - Royal Prince Alfred HospitalMichael Barnett - Royal Prince Alfred HospitalArkiev D'Souza - The University of SydneyFernando Calamante - The University of SydneyJoel Maamary - UNSW SydneyJames Peters - St Vincent's Hospital SydneyChenyu Wang - Cooperative Trials Group for Neuro-OncologyStephen Tisch - UNSW Sydney
- Resource Type
- Journal article
- Publication Details
- Frontiers in neurology, Vol.14, 1129430
- DOI
- 10.3389/fneur.2023.1129430
- PMID
- 37181561
- PMCID
- PMC10166854
- NLM abbreviation
- Front Neurol
- ISSN
- 1664-2295
- eISSN
- 1664-2295
- Publisher
- Frontiers Media Sa
- Number of pages
- 10
- Grant note
- GE Healthcare Australia Medical Physics PhD Scholarship
- Language
- English
- Date published
- 04/25/2023
- Academic Unit
- Radiology
- Record Identifier
- 9984848429802771
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