Journal article
Trenbolone acetate metabolites promote ovarian growth and development in adult Japanese medaka (Oryzias latipes)
General and comparative endocrinology, Vol.202, pp.1-7
06/01/2014
DOI: 10.1016/j.ygcen.2014.04.011
PMID: 24780119
Abstract
•Medaka exposed to trenbolone acetate metabolites had altered ovarian composition.•17α-Trenbolone significantly increased 17β-estradiol (pg/mg).•Trendione significantly decreased whole body 17β-estradiol and testosterone (pg/mg).•Trenbolone acetate metabolites were found to have estrogenic potential.
Trenbolone acetate, a synthetic androgen, has been used as a growth promoter in beef cattle in the US since 1987. While several teleost studies have investigated the masculinization effects of the metabolite 17β-trenbolone, few have focused on the reproductive impacts of all three trenbolone acetate (TBA) metabolites including trendione. Adult female medaka (Oryzias latipes) were exposed to TBA metabolites (10, 100, and 1000ng/L) for 14days (n=3). Histological examination revealed that TBA metabolites (1000ng/L) significantly reduced the percentage of primary ovarian follicles and increased the percentage of vitellogenic follicles compared to control fish. 17α-Trenbolone significantly increased whereas trendione reduced whole body levels of estradiol-17β. Testosterone was significantly reduced by trendione treatment and only the highest dose of 17β-trenbolone and lowest dose of trendione altered 11-ketotestosterone. Additionally, TBA metabolites may be further broken down and/or metabolized or converted by the animal influencing both sex steroid levels and ovarian development.
Details
- Title: Subtitle
- Trenbolone acetate metabolites promote ovarian growth and development in adult Japanese medaka (Oryzias latipes)
- Creators
- Kristy L Forsgren - Department of Environmental Sciences, University of California, Riverside, CA 92521, United StatesShen Qu - Department of Civil and Environmental Engineering, University of Iowa, Iowa City, IA 52242, United StatesRamon Lavado - Department of Environmental Sciences, University of California, Riverside, CA 92521, United StatesDavid Cwiertny - Department of Civil and Environmental Engineering, University of Iowa, Iowa City, IA 52242, United StatesDaniel Schlenk - Department of Environmental Sciences, University of California, Riverside, CA 92521, United States
- Resource Type
- Journal article
- Publication Details
- General and comparative endocrinology, Vol.202, pp.1-7
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.ygcen.2014.04.011
- PMID
- 24780119
- ISSN
- 0016-6480
- eISSN
- 1095-6840
- Language
- English
- Date published
- 06/01/2014
- Academic Unit
- Center for Health Effects of Environmental Contamination; Civil and Environmental Engineering; Public Policy Center (Archive); Chemistry; Chemical and Biochemical Engineering
- Record Identifier
- 9983991995002771
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