Journal article
Trends and correlates of monozygotic twinning after single embryo transfer
Obstetrics and gynecology (New York. 1953), Vol.125(1), pp.111-117
01/01/2015
DOI: 10.1097/AOG.0000000000000579
PMCID: PMC4515956
PMID: 25560112
Abstract
OBJECTIVETo evaluate trends of monozygotic twinning after single embryo transfer and its association with patient and treatment factors. METHODSOur retrospective cohort study included 28,596 pregnancies after fresh, nondonor single embryo transfer during 2003-2012 reported to the National ART Surveillance System. We examined trends of monozygotic twin pregnancies (number of fetal heart tones on first-trimester ultrasonography more than one or number of neonates born more than one) and assessed patient and treatment factors for monozygotic twin compared with singleton pregnancies. Modified Poisson regression models were used to estimate adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for association between monozygotic twinning and selected factors stratified by day 2-3 and day 5-6 transfer. RESULTSDuring 2003-2012, the incidence of monozygotic twinning after single embryo transfer was lower for day 2-3 transfers than for day 5-6 transfers (1.71%, 95% CI 1.45-1.98, n=162 compared with 2.50%, 95% CI 2.28-2.73, n=472); the incidence did not change significantly over the study period. Among day 2-3 transfers, assisted hatching increased the risk for monozygotic twinning compared with singletons (adjusted RR 2.16, 95% CI 1.53-3.06); use of intracytoplasmic sperm injection decreased the risk (adjusted RR 0.60, 95% CI 0.42-0.85). Having one or more prior pregnancies increased the risk for monozygotic twinning among day 5-6 transfers (adjusted RR 1.26, 95% CI 1.03-1.53). CONCLUSIONMonozygotic twinning after single embryo transfers was more common among day 5-6 embryo transfers than day 2-3 transfers. Use of assisted hatching was associated with increased risk for monozygotic twinning for day 2-3 transfers. LEVEL OF EVIDENCEII.
Details
- Title: Subtitle
- Trends and correlates of monozygotic twinning after single embryo transfer
- Creators
- Jessica R Kanter - National Center for Chronic Disease Prevention and Health PromotionSheree L Boulet - National Center for Chronic Disease Prevention and Health PromotionJennifer F Kawwass - Emory UniversityDenise J Jamieson - National Center for Chronic Disease Prevention and Health PromotionDmitry M Kissin - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- Obstetrics and gynecology (New York. 1953), Vol.125(1), pp.111-117
- DOI
- 10.1097/AOG.0000000000000579
- PMID
- 25560112
- PMCID
- PMC4515956
- NLM abbreviation
- Obstet Gynecol
- ISSN
- 1873-233X
- eISSN
- 1873-233X
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446540902771
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