Journal article
Trends and factors associated with the Day 5 embryo transfer, assisted reproductive technology surveillance, USA, 20012009
Human reproduction (Oxford), Vol.27(8), pp.2325-2331
08/01/2012
DOI: 10.1093/humrep/des168
PMID: 22627658
Abstract
What characteristics are associated with a Day 5 embryo transfer?
The use of the Day 5 embryo transfer has increased over time, with clinicians allowing women with typically opoorer' prognostic characteristics to undergo a Day 5 embryo transfer. The mean number of embryos per Day 5 transfer decreased from 2001 to 2009, although the prevalence of the Day 5 single embryo transfer remains low and the rate of multiple births remains substantial.
Day 5 embryo transfer may reduce the rate of multiple gestation pregnancy. US trends over time in the prevalence of the Day 5 transfer, changes in characteristics of patients receiving Day 5 transfer, and number of embryos transferred are unknown.
We used 20012009 US National assisted reproductive technology (ART) Surveillance System (NASS) data on 620 295 fresh IVF cycles derived from autologous oocytes with a Day 3 or 5 embryo transfer. Trends in the mean number of embryos transferred from 2001 to 2009 were assessed by the day of transfer. For 349 947 cycles from clinics performing both Days 3 and 5 embryo transfers, multivariable logistic regression was used to determine the characteristics associated with the Day 5 embryo transfer. We also compared the characteristics of the Day 5 embryo cycles in 2001 and 2009.
Overall, the proportion of ART cycles using the Day 5 embryo transfer increased from 12 in 2001 to 36 in 2009 (P 0.0001), while the mean number of embryos transferred decreased from 2.4 to 2.1 (P 0.0001). Among Day 5 transfers, the rate of the single embryo transfer tripled from 4.5 in 2001 to 14.8 in 2009 (P 0.0001); and the rate of multiple births decreased from 44.8 to 41.1 (P 0.0001). In cycles initiated after 2001, maternal age 35 years, no prior ART cycles, epsilon 1 prior pregnancies, baseline follicle stimulating hormone 10 international units and epsilon 10 oocytes retrieved were associated with the Day 5 embryo transfer. Compared with 2001, in 2009, a broader range of candidates received the Day 5 transfer.
Women undergoing multiple ART cycles over time are not linked.
We ran multivariable logistic regression to lessen the effects of the confounding factors. Cycle cancelation rates by the day of embryo transfer are unknown.
Generalizable to ART clinics included in NASS.
This study was funded by the Centres for Disease Control. The authors have no competing interests to declare.
Details
- Title: Subtitle
- Trends and factors associated with the Day 5 embryo transfer, assisted reproductive technology surveillance, USA, 20012009
- Creators
- Courtney A. Marsh - Michigan MedicineSherry L. Farr - Centers for Disease Control and PreventionJeani Chang - Centers for Disease Control and PreventionDmitry M. Kissin - Centers for Disease Control and PreventionDavid A. Grainger - Wichita State UniversitySamuel F. Posner - Centers for Disease Control and PreventionMaurizio Macaluso - Centers for Disease Control and PreventionDenise J. Jamieson - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- Human reproduction (Oxford), Vol.27(8), pp.2325-2331
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/humrep/des168
- PMID
- 22627658
- ISSN
- 0268-1161
- eISSN
- 1460-2350
- Number of pages
- 7
- Grant note
- Centers for disease control and prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA
- Language
- English
- Date published
- 08/01/2012
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446271202771
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