Journal article
Trends, characteristics, and incidence of anaphylaxis in 2001-2010: A population-based study
Journal of allergy and clinical immunology, Vol.139(1), pp.182-U258
01/01/2017
DOI: 10.1016/j.jaci.2016.04.029
PMCID: PMC5182191
PMID: 27378753
Abstract
Background: Anaphylaxis is a potentially life-threatening systemic allergic reaction. Objective: We aimed to determine the incidence rate and causes of anaphylaxis during a 10-year period in Olmsted County, Minnesota.
Methods: Using the resources of the Rochester Epidemiology Project, a comprehensive records linkage system, we performed a population-based incidence study in Olmsted County, Minnesota, from 2001 through 2010. All cases with a diagnosis of anaphylactic shock and 20% of cases with related diagnoses were manually reviewed. The relationships of age group, sex, and year of anaphylaxis with incidence rates were assessed by fitting Poisson regression models.
Results: Six hundred thirty-one cases of anaphylaxis were identified. The median age was 31 years (interquartile range, 19-44 years). The overall age-and sex-adjusted incidence rate was 42 (95% CI, 38.7-45.3) per 100,000 person-years. There was a significant increase in the overall incidence of anaphylaxis during the study period, with an average increase of 4.3% per year (P < .001). In addition, there was a 9.8% increase per year in the incidence rate of food-related anaphylaxis. Food-related anaphylaxis was most common in children aged 0 to 9 years, venom-related anaphylaxis was most common in those 20 to 39 years of age, and medication-related anaphylaxis was most common in those 30 to 39 years of age.
Conclusion: The overall incidence rate of anaphylaxis was 42 per 100,000 person-years from 2001-2010 in Olmsted County, Minnesota. The incidence of anaphylaxis increased over time, and several inciting triggers were uniquely associated with different age groups.
Details
- Title: Subtitle
- Trends, characteristics, and incidence of anaphylaxis in 2001-2010: A population-based study
- Creators
- Sangil Lee - Mayo Clinic Health SystemErik P. Hess - Mayo Clinic in FloridaChristine Lohse - Mayo Clinic in FloridaWaqas Gilani - Mayo ClinicAlanna M. Chamberlain - Mayo ClinicRonna L. Campbell - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.139(1), pp.182-U258
- DOI
- 10.1016/j.jaci.2016.04.029
- PMID
- 27378753
- PMCID
- PMC5182191
- NLM abbreviation
- J Allergy Clin Immunol
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- UL1TR000135 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01AG034676 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01AR030582 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) R01AG034676 / National Institute on Aging of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) UL1 TR000135 / CTSA grant from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Language
- English
- Date published
- 01/01/2017
- Academic Unit
- Emergency Medicine; Injury Prevention Research Center
- Record Identifier
- 9984297135302771
Metrics
28 Record Views