Journal article
Trends in Antifungal Use and Epidemiology of Nosocomial Yeast Infections in a University Hospital
Journal of clinical microbiology, Vol.37(3), pp.531-537
03/1999
DOI: 10.1128/JCM.37.3.531-537.1999
PMCID: PMC84452
PMID: 9986807
Abstract
This report describes both the trends in antifungal use and the epidemiology of nosocomial yeast infections at the University of Iowa Hospitals and Clinics between fiscal year (FY) 1987–1988 and FY 1993–1994. Data were gathered retrospectively from patients’ medical records and from computerized databases maintained by the Pharmacy, the Program of Hospital Epidemiology, and the Medical Records Department. After fluconazole was introduced, use of ketoconazole decreased dramatically but adjusted use of amphotericin B decreased only moderately. However, the proportion of patients receiving antifungal therapy who were treated with amphotericin B declined markedly. In FY 1993–1994, 26 patients of the gastrointestinal surgery service received fluconazole. Among these patients, fluconazole use was prophylactic in 16 (61%), empiric in 3 (12%), and directed to a documented fungal infection in 7 (27%). Rates of nosocomial yeast infection in the adult bone marrow transplant unit increased from 6.77/1,000 patient days in FY 1987–1988 to 10.18 in FY 1989–1990 and then decreased to 0 in FY 1992–1993. Rates of yeast infections increased threefold in the medical and surgical intensive care units, reaching rates in FY 1993–1994 of 6.95 and 5.25/1,000 patient days, respectively. The rate of bloodstream infections increased from 0.044/1,000 patient days to 0.098, and the incidence of catheter-related urinary tract infections increased from 0.23/1,000 patient days to 0.68. Although the proportion of infections caused by yeast species other than
Candida albicans
did not increase consistently,
C. glabrata
became an important nosocomial pathogen.
Details
- Title: Subtitle
- Trends in Antifungal Use and Epidemiology of Nosocomial Yeast Infections in a University Hospital
- Creators
- Yasmina F Berrouane - Departments of Internal MedicineLoreen A Herwaldt - Departments of Internal MedicineMichael A Pfaller - Departments of Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.37(3), pp.531-537
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/JCM.37.3.531-537.1999
- PMID
- 9986807
- PMCID
- PMC84452
- ISSN
- 0095-1137
- eISSN
- 1098-660X
- Language
- English
- Date published
- 03/1999
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9984094878202771
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