Journal article
Trends in Corticosteroid Use Among Males With Duchenne Muscular Dystrophy (DMD) During 2000-2015: Data From the MD STARnet
Journal of child neurology, Vol.41(4), pp.505-519
04/2026
DOI: 10.1177/08830738251367466
PMID: 40879420
Abstract
This study updates previous reports by the population-based Muscular Dystrophy Surveillance, Tracking and Research Network on associations between increased corticosteroid use over time, and delayed use of corticosteroids among non-Hispanic Black males and those having a positive family history of Duchenne muscular dystrophy. Data for 373 males from six sites born and followed during 2000-2015 were analyzed using Kaplan-Meier curve estimation and Cox proportional hazards modeling. Corticosteroids were offered to 75.6% of all males; 68.9% initiated use at median ages of 6.8 (offered) and 7.2 (used). The previously observed associations persisted. Further examination of these associations suggest diagnosis timing may partially account for the observed delays due to later diagnosis among non-Hispanic Black males and early diagnosis among those with a positive Duchenne muscular dystrophy family history. Further research into health inequities underlying diagnostic delays among non-Hispanic Black males and the safety profile of early corticosteroid use will further inform on variability in corticosteroid treatment.
Details
- Title: Subtitle
- Trends in Corticosteroid Use Among Males With Duchenne Muscular Dystrophy (DMD) During 2000-2015: Data From the MD STARnet
- Creators
- Shiny Thomas - New York State Department of HealthTahereh Neyaz - University of IowaKristin M. Conway - University of Iowa, EpidemiologyAida Soim - New York State Department of HealthPaul A. Romitti - University of IowaCarla Zingariello - University of FloridaJoshua R. Mann - University of Mississippi Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of child neurology, Vol.41(4), pp.505-519
- DOI
- 10.1177/08830738251367466
- PMID
- 40879420
- NLM abbreviation
- J Child Neurol
- ISSN
- 0883-0738
- eISSN
- 1708-8283
- Publisher
- Sage
- Grant note
- Centers for Disease Control and Prevention (http://data.elsevier.com/vocabulary/SciValFunders/100000030)
- Language
- English
- Electronic publication date
- 08/29/2025
- Date published
- 04/2026
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984958609402771
Metrics
5 Record Views