Journal article
Trends in Mortality From Parkinson Disease in the United States, 1999-2019
Neurology, Vol.97(20), pp.e1986-E1993
11/16/2021
DOI: 10.1212/WNL.0000000000012826
PMID: 34706971
Abstract
The mortality from Parkinson disease (PD) and its long-term trends in the United States in recent decades remains unknown. This study aimed to describe the trends in PD mortality in the United States from 1999 to 2019.
We used data from the National Vital Statistics System, a nationwide, population-based death registry, to determine national trends in PD mortality, overall and by age, sex, race/ethnicity, urban-rural classification, and geographic location. Analyses focused on the data from 479,059 deaths due to PD from 1999 to 2019. Joinpoint regression was performed to examine temporal trends in age-adjusted death rates.
The age-adjusted mortality from PD increased from 5.4 (95% confidence interval [CI] 5.3-5.5) per 100,000 population in 1999 to 8.8 (95% CI, 8.7-8.9) per 100,000 population in 2019, with an average annual percent change of 2.4% (95% CI, 1.8%-3.0%). From 1999 to 2019, PD mortality increased significantly across all age groups, both sexes, various racial/ethnic groups, and different urban-rural classifications. The US states and District of Columbia with reported death rates all experienced an increase in PD mortality. Significant differences by sex and race/ethnicity were noted. Age-adjusted PD mortality rates were twice as high in men as in women and were greater in White individuals than those from other racial/ethnic groups.
From 1999 to 2019, the mortality from PD in the United States has increased significantly. The increase was regardless of age, sex, race/ethnicity, urban-rural classification, and geographic location. A comprehensive evaluation of long-term trends in PD mortality is important for health care priority setting.
Details
- Title: Subtitle
- Trends in Mortality From Parkinson Disease in the United States, 1999-2019
- Creators
- Shuang Rong - From the Department of Nutrition and Food Hygiene (S.R., B.L., J.L.), School of Public Health, Medical College, Wuhan University of Science and Technology, China; and Department of Epidemiology (S.R., G.X., B.L., Y.S., L.G.S., R.B.W., W.B.), College of Public Health, University of Iowa, Iowa CityGuifeng Xu - From the Department of Nutrition and Food Hygiene (S.R., B.L., J.L.), School of Public Health, Medical College, Wuhan University of Science and Technology, China; and Department of Epidemiology (S.R., G.X., B.L., Y.S., L.G.S., R.B.W., W.B.), College of Public Health, University of Iowa, Iowa CityBuyun Liu - From the Department of Nutrition and Food Hygiene (S.R., B.L., J.L.), School of Public Health, Medical College, Wuhan University of Science and Technology, China; and Department of Epidemiology (S.R., G.X., B.L., Y.S., L.G.S., R.B.W., W.B.), College of Public Health, University of Iowa, Iowa CityYangbo Sun - From the Department of Nutrition and Food Hygiene (S.R., B.L., J.L.), School of Public Health, Medical College, Wuhan University of Science and Technology, China; and Department of Epidemiology (S.R., G.X., B.L., Y.S., L.G.S., R.B.W., W.B.), College of Public Health, University of Iowa, Iowa CityLinda G Snetselaar - From the Department of Nutrition and Food Hygiene (S.R., B.L., J.L.), School of Public Health, Medical College, Wuhan University of Science and Technology, China; and Department of Epidemiology (S.R., G.X., B.L., Y.S., L.G.S., R.B.W., W.B.), College of Public Health, University of Iowa, Iowa CityRobert B Wallace - From the Department of Nutrition and Food Hygiene (S.R., B.L., J.L.), School of Public Health, Medical College, Wuhan University of Science and Technology, China; and Department of Epidemiology (S.R., G.X., B.L., Y.S., L.G.S., R.B.W., W.B.), College of Public Health, University of Iowa, Iowa CityBenchao Li - From the Department of Nutrition and Food Hygiene (S.R., B.L., J.L.), School of Public Health, Medical College, Wuhan University of Science and Technology, China; and Department of Epidemiology (S.R., G.X., B.L., Y.S., L.G.S., R.B.W., W.B.), College of Public Health, University of Iowa, Iowa CityJingling Liao - From the Department of Nutrition and Food Hygiene (S.R., B.L., J.L.), School of Public Health, Medical College, Wuhan University of Science and Technology, China; and Department of Epidemiology (S.R., G.X., B.L., Y.S., L.G.S., R.B.W., W.B.), College of Public Health, University of Iowa, Iowa CityWei Bao - From the Department of Nutrition and Food Hygiene (S.R., B.L., J.L.), School of Public Health, Medical College, Wuhan University of Science and Technology, China; and Department of Epidemiology (S.R., G.X., B.L., Y.S., L.G.S., R.B.W., W.B.), College of Public Health, University of Iowa, Iowa City. drwbao@hotmail.com
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.97(20), pp.e1986-E1993
- DOI
- 10.1212/WNL.0000000000012826
- PMID
- 34706971
- NLM abbreviation
- Neurology
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 11/16/2021
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984215049602771
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