Journal article
Trends in United States Prostate Cancer Incidence Rates by Age and Stage, 1995-2012
Cancer epidemiology, biomarkers & prevention, Vol.25(2), pp.259-263
02/2016
DOI: 10.1158/1055-9965.EPI-15-0723
PMID: 26646364
Abstract
The advent of PSA testing in the late 1980s substantially increased prostate cancer incidence rates. Concerns about overscreening and overdiagnosis subsequently led professional guidelines (circa 2000 and later) to recommend against routine PSA testing. We evaluated trends in prostate cancer incidence, including late-stage diagnoses, from 1995 through 2012.
We used joinpoint regression analyses to evaluate all-, localized/regional-, and distant-stage prostate cancer incidence trends based on Surveillance, Epidemiology, and End Results (SEER) data. We stratified analyses by age (50-69, 70+). We reported incidence trends as annual percent change (APC).
Overall age-adjusted incidence rates for localized/regional stage prostate cancer have been declining since 2001, sharply from 2010 to 2012 [APC, -13.1; 95% confidence intervals (CI), -23.5 to -1.3]. Distant-stage incidence rates have declined since 1995, with greater declines from 1995 to 1997 (APC, -8.4; 95% CI, -2.3 to -14.1) than from 2003 to 2012 (APC, -1.0; 95% CI, -1.7 to -0.4). Distant-stage incidence rates declined for men ages 70+ from 1995 to 2012, but increased in men ages 50 to 69 years from 2004 to 2012 (APC, 1.7; 95% CI, 0.2 to 3.2).
Guidelines discouraging routine prostate cancer screening were temporally associated with declining localized/regional prostate cancer incidence rates; however, incidence rates of distant-stage disease are now increasing in younger men.
This trend may adversely affect prostate cancer mortality rates.
Details
- Title: Subtitle
- Trends in United States Prostate Cancer Incidence Rates by Age and Stage, 1995-2012
- Creators
- Richard M Hoffman - Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa. Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa. richard-m-hoffman@uiowa.eduAngela L W Meisner - University of New Mexico Comprehensive Cancer Center, Albuquerque, New MexicoWadih Arap - University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico. Department of Internal Medicine, University of New Mexico, Albuquerque, New MexicoMarc Barry - University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico. Department of Pathology, University of New Mexico, Albuquerque, New MexicoSatyan K Shah - University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico. Department of Surgery, University of New Mexico, Albuquerque, New MexicoSteven B Zeliadt - Puget Sound VA Healthcare System, Seattle, WashingtonCharles L Wiggins - University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico. Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.25(2), pp.259-263
- DOI
- 10.1158/1055-9965.EPI-15-0723
- PMID
- 26646364
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Grant note
- I01 HX000940 / HSRD VA 2P30CA118100-1 / NCI NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 02/2016
- Academic Unit
- Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094529502771
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