Journal article
Trends in sex differences in neurodevelopmental outcomes among extremely preterm infants
Archives of disease in childhood. Fetal and neonatal edition, Vol.110(3), pp.269-278
05/2025
DOI: 10.1136/archdischild-2024-327239
PMCID: PMC11922790
PMID: 39288987
Abstract
ObjectiveTo examine whether changes in survival without moderate or severe neurodevelopmental impairment (NDI) at 18–26 months’ corrected age from 1999 to 2018 differed between male and female infants.DesignThis retrospective cohort study used data from the NICHD Neonatal Research Network hospitals. Robust Poisson regression models were used to estimate adjusted relative risks (aRRs) and 95% CIs for survival without moderate or severe NDI between males and females. Interactions between sex and time were assessed to evaluate temporal differences in the outcome by sex. Variables adjusted for included centre, maternal age, ethnicity/race, gestational age and small for gestational age.PatientsInborn infants with gestational age of 22–26 weeks at NICHD Neonatal Research Network hospitals from 1999 to 2018.Main outcome measureChange over time in survival without moderate or severe NDI at 18–26 months’ corrected age between male and female infants.ResultsOf 26 307 infants, 13 045 (49.6%) were male. Survival without moderate or severe NDI declined for both sexes over time, from 32.9% to 30.6% for males and from 47.4% to 40.0% for females, between 1999–2003 and 2014–2018. Males were less likely than females to survive without moderate or severe NDI (aRR=0.80; 95% CI 0.78 to 0.83). Changes in survival without moderate or severe NDI did not differ between males and females.ConclusionThere were no differential changes in survival without moderate or severe NDI between male and female infants.
Details
- Title: Subtitle
- Trends in sex differences in neurodevelopmental outcomes among extremely preterm infants
- Creators
- Nansi S Boghossian - University of South CarolinaNicole A Mack - RTI InternationalEdward F Bell - University of IowaSylvia Tan - RTI InternationalBarbara J Stoll - Emory UniversityMatthew A Rysavy - The University of Texas Health Science Center at HoustonNamasivayam Ambalavanan - University of Alabama at BirminghamJon E Tyson - The University of Texas Health Science Center at HoustonAbhik Das - RTI InternationalSusan R Hintz - Stanford UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research NetworkTarah T Colaizy (Contributor) - University of IowaJohn A Widness (Contributor) - University of IowaHeidi M Harmon (Contributor) - University of IowaJane E Brumbaugh (Contributor) - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Archives of disease in childhood. Fetal and neonatal edition, Vol.110(3), pp.269-278
- DOI
- 10.1136/archdischild-2024-327239
- PMID
- 39288987
- PMCID
- PMC11922790
- NLM abbreviation
- Arch Dis Child Fetal Neonatal Ed
- ISSN
- 1359-2998
- eISSN
- 1468-2052
- Publisher
- BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health; LONDON
- Grant note
- R01MD016012 / National Institute on Minority Health and Health Disparities (http://dx.doi.org/10.13039/100006545)
- Language
- English
- Electronic publication date
- 09/20/2024
- Date published
- 05/2025
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984705601202771
Metrics
7 Record Views