Trends of Diabetes in Youth (TrenDY) during COVID-19 across the United States

Amit Lahoti; Md Rejuan Haque; Monica E Bianco; Abha Chaudhary; Amy L Clark; Brynn E Marks; Catherina T Pinnaro; Amy S Shah; Margaret A Stefater-Richards; Vidhu V Thaker; Risa M Wolfe; Jeanie B Tryggestad; Trends of Diabetes in Youth (TrenDY) Consortium

doi:10.1210/clinem/dgaf395

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Trends of Diabetes in Youth (TrenDY) during COVID-19 across the United States

Journal article

Open access

Peer reviewed

Trends of Diabetes in Youth (TrenDY) during COVID-19 across the United States

Amit Lahoti, Md Rejuan Haque, Monica E Bianco, Abha Chaudhary, Amy L Clark, Brynn E Marks, Catherina T Pinnaro, Amy S Shah, Margaret A Stefater-Richards, Vidhu V Thaker, …

The journal of clinical endocrinology and metabolism, Vol.111(2), pp.e476-e483

01/21/2026

DOI: 10.1210/clinem/dgaf395

PMCID: PMC12520849

PMID: 40658807

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Abstract

The frequency and acuity at diagnosis of youth-onset type 1 diabetes (T1D) and type 2 diabetes (T2D) was reported as higher in the first year of the COVID-19 pandemic, but it is unclear if these trends persist. To describe trends in new cases of youth-onset diabetes comparing the first 2 years of the COVID-19 pandemic with the 2 preceding years. Retrospective study. 23 clinical centers in the US. New-onset T1D and T2D in youth between March 1,2018 and February 28,2022.Main Outcome Measures: New diagnosis of youth-onset T1D or T2D and acuity at diagnosis. A total of 4,851 youth were diagnosed with T1D in the pre-pandemic period (Yr 1: March 1,2018 to February 28,2019, Yr 2: March 1,2019 to February 29,2020) and 5,955 individuals during pandemic (Yr 3: March 1,2020 to February 29,2021, Yr 4: March 1,2021 to February 28,2022), a 22.8% increase (ns). Proportion of DKA in T1D was higher during (43.41%) vs pre-pandemic (37.77%, p<0.01). For T2D, 1610 youth were diagnosed in the pre-pandemic period while 3443 patients were diagnosed with T2D during pandemic (a 114% increase). The increase in frequency of T2D attributable to pandemic from Yr 2 to Yr 3 was 76.8% (p<0.01), while the increase from Yr 3 to Yr 4 was not significant. In youth, the frequency of both T1D and T2D increased during the COVID-19 pandemic but was significant only for T2D. When controlled for yearly trends, only frequency of T2D increased significantly in the first year of pandemic suggesting that the pandemic environment differentially impacted rates of T1D and T2D in youth.

COVID

Type 1 Diabetes

Type 2 Diabetes

youth

Details

Title: Subtitle: Trends of Diabetes in Youth (TrenDY) during COVID-19 across the United States
Creators: Amit Lahoti - Nationwide Children's Hospital
Md Rejuan Haque - The Ohio State University
Monica E Bianco - Northwestern University
Abha Chaudhary - The University of Texas Southwestern Medical Center
Amy L Clark - Cardinal Glennon Children’s Medical Center
Brynn E Marks - Children's Hospital of Philadelphia
Catherina T Pinnaro - University of Iowa
Amy S Shah - Cincinnati Children's Hospital Medical Center
Margaret A Stefater-Richards - Boston Children's Museum
Vidhu V Thaker - Morgan Stanley Children's Hospital
Risa M Wolfe - Johns Hopkins Hospital
Jeanie B Tryggestad - University of Oklahoma Health Sciences Center
Trends of Diabetes in Youth (TrenDY) Consortium
Resource Type: Journal article
Publication Details: The journal of clinical endocrinology and metabolism, Vol.111(2), pp.e476-e483
DOI: 10.1210/clinem/dgaf395
PMID: 40658807
PMCID: PMC12520849
NLM abbreviation: J Clin Endocrinol Metab
ISSN: 0021-972X
eISSN: 1945-7197
Language: English
Electronic publication date: 07/14/2025
Date published: 01/21/2026
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics
Record Identifier: 9984847993102771

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