Journal article
Trends of lymphoma incidence in US veterans with rheumatoid arthritis, 2002–2017
Rheumatic & musculoskeletal diseases open, Vol.6(2), p.e001241
07/08/2020
DOI: 10.1136/rmdopen-2020-001241
PMCID: PMC7425185
PMID: 32646953
Abstract
ObjectivePast epidemiological studies have consistently demonstrated a link between rheumatoid arthritis (RA) and the incidence of lymphoma and it has been posited that high systemic inflammatory activity is a major risk determinant of lymphomagenesis. Given advances in the therapeutic armamentarium for RA management in recent years, the resulting lower level of disease activity could have led to a decline in lymphoma incidence in patients with RA. This study examined recent trends in lymphoma incidence in US veterans with RA.MethodsPatients with RA were identified in the Veterans Affairs (VA) Corporate Data Warehouse. Lymphoma incidence was identified through the end of 2018 from the VA Central Cancer Registry and compared among patients diagnosed during 2003–2005, 2006–2008, 2009–2011 and 2012–2014.ResultsAmong persons diagnosed with RA during 2003–2005, the incidence of lymphoma in the next 6 years was 2.0 per 1000 person-years. There was a steady decline in lymphoma incidence during the corresponding 6 years following diagnosis in the subsequent three cohorts, with a rate of 1.5 per 1000 person-years in the 2012–2014 cohort (incidence relative to that in the 2003–2005 cohort=0.79 (95% CI 0.58 to 1.1)). There was no similar decline in lymphoma incidence in VA patients diagnosed with osteoarthritis.ConclusionWe observed a decline in lymphoma incidence in recent years among American veterans with RA. Further studies are needed to evaluate the specific factors driving this decline.
Details
- Title: Subtitle
- Trends of lymphoma incidence in US veterans with rheumatoid arthritis, 2002–2017
- Creators
- Namrata Singh - Rheumatology, University of Washington, Seattle, Washington, USAYubo Gao - Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAElizabeth Field - Division of Immunology, Department of Internal Medicine, The University of Iowa, Iowa City, Iowa, USABrian K Link - University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USANoel Weiss - Department of Epidemiology, University of Washington, Seattle, Washington, USAJeffrey R Curtis - Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USACharles F Lynch - Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa, USAMary Vaughan-Sarrazin - Division of Immunology, Department of Internal Medicine, The University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Rheumatic & musculoskeletal diseases open, Vol.6(2), p.e001241
- DOI
- 10.1136/rmdopen-2020-001241
- PMID
- 32646953
- PMCID
- PMC7425185
- NLM abbreviation
- RMD Open
- ISSN
- 2056-5933
- eISSN
- 2056-5933
- Grant note
- DOI: 10.13039/100000048, name: American Cancer Society, award: IRG-15-176-41
- Language
- English
- Date published
- 07/08/2020
- Academic Unit
- Health Management and Policy; Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Immunology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984214800502771
Metrics
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