Trial design: Blood pressure control and weight gain prevention in prehypertensive and hypertensive smokers: The treatment and prevention study

Mark W Vander Weg; Robert C Klesges; Jon O Ebbert; Ellen J Lichty; Margaret DeBon; Frederick North; Darrell R Schroeder; Patricia M Dubbert

doi:10.1016/j.cct.2007.07.003

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Trial design: Blood pressure control and weight gain prevention in prehypertensive and hypertensive smokers: The treatment and prevention study

Journal article

Peer reviewed

Trial design: Blood pressure control and weight gain prevention in prehypertensive and hypertensive smokers: The treatment and prevention study

Mark W Vander Weg, Robert C Klesges, Jon O Ebbert, Ellen J Lichty, Margaret DeBon, Frederick North, Darrell R Schroeder and Patricia M Dubbert

Contemporary clinical trials, Vol.29(2), pp.281-292

2008

DOI: 10.1016/j.cct.2007.07.003

PMCID: PMC4275108

PMID: 17716953

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http://doi.org/10.1016/j.cct.2007.07.003View

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Abstract

Cigarette smokers with elevated blood pressure (BP) are at substantially higher risk for cardiovascular events compared to normotensive smokers. Although smoking cessation should be a primary treatment goal for these patients, increases in body weight accompanying smoking abstinence may further increase BP. Intervention strategies that facilitate smoking cessation and modify adverse changes in body weight and BP are needed. We describe an ongoing multi-site, two-phase, five-year randomized clinical trial. Participants are cigarette smokers with Prehypertension or Stage I Hypertension. In the first phase, participants receive a smoking cessation intervention combining behavioral counseling and nicotine replacement in an open-label fashion. In the second phase, participants who successfully quit smoking are randomly assigned to one of three lifestyle interventions: 1) weight gain prevention, 2) blood pressure control, or 3) usual lifestyle. Participants are followed for one year to assess changes in blood pressure, body weight, dietary intake, and physical activity. Results from the proposed study will provide important insights into the efficacy of various approaches to lifestyle modification in smokers at increased risk for cardiovascular events.

Hypertension

Cardiovascular disease

Blood pressure

Cigarette smoking

Lifestyle modification

Body weight

Details

Title: Subtitle: Trial design: Blood pressure control and weight gain prevention in prehypertensive and hypertensive smokers: The treatment and prevention study
Creators: Mark W Vander Weg - Iowa City VA Medical Center, Center for Research in the Implementation of Innovative Strategies in Practice (CRIISP), Iowa City, IA, USA
Robert C Klesges - University of Tennessee Health Science Center, Memphis, TN, USA
Jon O Ebbert - Mayo Clinic College of Medicine, Rochester, MN, USA
Ellen J Lichty - Mayo Clinic College of Medicine, Rochester, MN, USA
Margaret DeBon - University of Tennessee Health Science Center, Memphis, TN, USA
Frederick North - Mayo Clinic College of Medicine, Rochester, MN, USA
Darrell R Schroeder - Mayo Clinic College of Medicine, Rochester, MN, USA
Patricia M Dubbert - GV (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS, USA
Resource Type: Journal article
Publication Details: Contemporary clinical trials, Vol.29(2), pp.281-292
DOI: 10.1016/j.cct.2007.07.003
PMID: 17716953
PMCID: PMC4275108
NLM abbreviation: Contemp Clin Trials
ISSN: 1551-7144
eISSN: 1559-2030
Publisher: Elsevier Inc
Language: English
Date published: 2008
Academic Unit: Psychological and Brain Sciences; Injury Prevention Research Center; Community and Behavioral Health; Internal Medicine
Record Identifier: 9984064192502771

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