Journal article
Trichomonas vaginalis infection activates cells through toll-like receptor 4
Clinical immunology (Orlando, Fla.), Vol.111(1), pp.103-107
2004
DOI: 10.1016/j.clim.2003.12.008
PMID: 15093558
Abstract
While
Trichomonas vaginalis infection can cause inflammation and influx of leukocytes into the female genital tract, the molecular pathways important in inducing these effects are not known. This study determined if infection with
T. vaginalis activates cells through toll-like receptor 4 (TLR4). Genital tract secretions from infected women stimulated TNF-α production by cells with functional TLR4 (350 pg/ml) but significantly less by cells that are unresponsive to TLR4 ligands (44 pg/ml,
P = 0.001). Secretions collected after clearance of infection also induced significantly lower responses by cells with functional TLR4 (136 pg/ml,
P = 0.008). TNF-α responses were not reduced by Polymyxin B and did not correlate with β
2-defensin levels, indicating that stimulation of cells was not through lipopolysaccharide or β
2-defensin. These studies show that
T. vaginalis infection results in the appearance in the genital tract of substance(s) that stimulate cells through TLR4, suggesting a mechanism for the inflammation caused by this infection.
Details
- Title: Subtitle
- Trichomonas vaginalis infection activates cells through toll-like receptor 4
- Creators
- M.Reza Zariffard - Department of Immunology/Microbiology, Rush University, Chicago, IL 60612, USASailesh Harwani - Department of Immunology/Microbiology, Rush University, Chicago, IL 60612, USARichard M Novak - Section of Infectious Diseases, University of Illinois at Chicago, Chicago, IL 60612, USAParrie J Graham - Section of Infectious Diseases, University of Illinois at Chicago, Chicago, IL 60612, USAXin Ji - Department of Immunology/Microbiology, Rush University, Chicago, IL 60612, USAGregory T Spear - Department of Immunology/Microbiology, Rush University, Chicago, IL 60612, USA
- Resource Type
- Journal article
- Publication Details
- Clinical immunology (Orlando, Fla.), Vol.111(1), pp.103-107
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.clim.2003.12.008
- PMID
- 15093558
- ISSN
- 1521-6616
- eISSN
- 1521-7035
- Language
- English
- Date published
- 2004
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094717702771
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