Journal article
Tricyclic antidepressant concentrations in plasma: An estimate of their sensitivity and specificity as a predictor of response
Journal of clinical psychopharmacology, Vol.14(4), pp.230-240
08/01/1994
DOI: 10.1097/00004714-199408000-00002
PMID: 7962678
Abstract
An analysis of the literature on tricyclic antidepressant level in blood using receiver operating characteristics curves as the primary statistical tool was performed. For nortriptyline, a significant curvilinear relationship between therapeutic response and nortriptyline was observed that ranged from 58 to 148 ng/ml. The sensitivity and specificity for the nortriptyline therapeutic window were 78 and 61%, respectively. The response rate within the therapeutic range was 66% versus 26% outside the therapeutic range. For desipramine, a significant linear relationship between therapeutic response and desipramine concentration in plasma was observed. The threshold concentration in plasma for therapeutic response was 116 ng/ml. The sensitivity and specificity for the desipramine threshold level in blood were 81 and 59%, respectively. The response rate above the threshold level was 51% versus 15% below the therapeutic threshold concentration. For imipramine, a significant curvilinear relationship between therapeutic response and total imipramine (imipramine+desipramine) concentration in plasma was observed between 175 and 350 ng/ml. The sensitivity and specificity for the total imipramine concentrations in plasma were 52 and 74%, respectively. The response rate within the therapeutic range was 67% versus 39% outside the therapeutic range. For amitriptyline, a significant curvilinear relationship between therapeutic response and total amitriptyline (amitriptyline+nortriptyline) concentration in plasma was observed between 93 and 140 ng/ml. The sensitivity and specificity for the total imipramine concentrations in plasma were 37 and 80%, respectively. The response rate within the therapeutic range was 50% versus 30% outside the therapeutic range.
Details
- Title: Subtitle
- Tricyclic antidepressant concentrations in plasma: An estimate of their sensitivity and specificity as a predictor of response
- Creators
- Paul J. Perry - University of IowaCarla Zeilmann - University of IowaStephan Arndt - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of clinical psychopharmacology, Vol.14(4), pp.230-240
- DOI
- 10.1097/00004714-199408000-00002
- PMID
- 7962678
- ISSN
- 0271-0749
- eISSN
- 1533-712X
- Number of pages
- 11
- Language
- English
- Date published
- 08/01/1994
- Academic Unit
- Pharmacy; Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9985132075002771
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