Journal article
Tricyclic antidepressants: Potent blockade of histamine H1 receptors of guinea pig ileum
European journal of pharmacology, Vol.58(4), pp.479-483
10/1979
DOI: 10.1016/0014-2999(79)90320-0
PMID: 41726
Abstract
Six tricyclic antidepressants were tested for their ability to antagonize histamine actions at histamine H1 receptors in a bioassay for these receptors (histamine-induced contractions of guinea pig ileum). All compounds were competitive antagonists with equilibrium dissociation constants in the range of 5.6 x 10(-11) M to 1.5 x 10(-7) M. Doxepin hydrochloride and amitriptyline hydrochloride were the most potent compounds of the series and may be the most potent antihistamines known. Antagonism at histamine H1 receptors by these compounds may explain their sedative effects.
Details
- Title: Subtitle
- Tricyclic antidepressants: Potent blockade of histamine H1 receptors of guinea pig ileum
- Creators
- James FiggePaul LeonardElliott Richelson
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.58(4), pp.479-483
- DOI
- 10.1016/0014-2999(79)90320-0
- PMID
- 41726
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 10/1979
- Academic Unit
- Anesthesia
- Record Identifier
- 9984006311302771
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