Journal article
Trigeminal nerve blocks attenuate afferent input to the puff-induced blink reflex in chronic orbital pain assessed by high-speed video
Orbit (Amsterdam), Vol.44(4), pp.375-383
07/04/2025
DOI: 10.1080/01676830.2024.2435951
PMID: 39671190
Abstract
To assess the trigeminal blink reflex in chronic orbital pain and its modification by orbital anesthetic injections using a novel blink reflexometer.
The EyeStat (Generation 3, Blinktbi, Inc. Charleston, SC) is a device that triggers and analyzes the carbon dioxide puff-evoked trigeminal blink response. In this prospective study, CO
puffs were delivered to each eye of 6 patients with unilateral, chronic orbital pain at baseline and 30 minutes after unilateral orbital anesthetic injections consisting of lidocaine and bupivacaine. Ten healthy subjects underwent the testing once without injections. Main outcome measures were comparison of the average of the right and left eyelid responses to stimuli given to the right or left eye (to assess afferent response in the right vs left eye) and comparison of the right eyelid to left eyelid responses to both the right and left stimuli (to assess efferent response in the right vs left eye).
In 10 healthy patients, direct blink response of the stimulated eyelid exceeded the consensual response of the opposite eyelid (latency
= .001, excursion
= .04, time to close
= .03). Among the 6 pain patients, eyelid kinematics for afferent trigeminal input were similar between the affected eye and the fellow eye. However, after injection, the afferent latency of the affected eye was significantly prolonged relative to the unaffected eye (
= .006). Efferent blink responses were similar between the two eyelids at all time points.
Peribulbar anesthetic injections modulate mechanical afferent input to the trigeminal blink reflex.
Details
- Title: Subtitle
- Trigeminal nerve blocks attenuate afferent input to the puff-induced blink reflex in chronic orbital pain assessed by high-speed video
- Creators
- Grace Lee - Carver College of Medicine, University of Iowa, Iowa City, Iowa, USAJulie Nellis - Department of Veteran's Affairs Center for the Prevention and Treatment of Visual Loss, Research Division, Iowa City, Iowa, USAChau M Pham - University of IowaRandy H Kardon - Department of Veteran's Affairs Center for the Prevention and Treatment of Visual Loss, Research Division, Iowa City, Iowa, USAErin M Shriver - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Orbit (Amsterdam), Vol.44(4), pp.375-383
- DOI
- 10.1080/01676830.2024.2435951
- PMID
- 39671190
- NLM abbreviation
- Orbit
- ISSN
- 0167-6830
- eISSN
- 1744-5108
- Publisher
- TAYLOR & FRANCIS INC
- Grant note
- University of Iowa Department of Ophthalmology and Visual SciencesVeterans Affairs Center for the Prevention and Treatment of Visual Loss (CPTVL)National Institute of Health: R01 EY031544, R21 EY032399 Veteran's Affairs: 1I50RX003002, 1I01 RX003797, C2978-R
Research to Prevent Blindness, New York, NY - unrestricted grant to the University of Iowa Department of Ophthalmology and Visual Sciences. Veterans Affairs Center for the Prevention and Treatment of Visual Loss (CPTVL) - pilot grant. R.H.K received funding from the National Institute of Health [R01 EY031544]; [R21 EY032399] and the Veteran's Affairs [grants [1I50RX003002]; [1I01 RX003797]; [C2978-R].
- Language
- English
- Electronic publication date
- 12/13/2024
- Date published
- 07/04/2025
- Academic Unit
- Iowa Neuroscience Institute; Otolaryngology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984757468902771
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