Journal article
Trimming the fat: a brief review of lipids at the host-pathogen interface
Infection and immunity, Vol.93(7), e00506-24
07/08/2025
DOI: 10.1128/iai.00506-24
PMCID: PMC12234433
PMID: 40512027
Abstract
Microbial-derived lipids and the host receptors that bind them are collectively critical for immune regulation on the host side and for a multitude of biological functions on the microbial side, including membrane structure, energy generation, resistance to stress, and, importantly, virulence. Bacteria, viruses, fungi, and eukaryotic microorganisms comprise common and unique lipid species that can be modified to avoid immune detection and aid in antimicrobial resistance. Moreover, the host receptors that interact with lipids are equally diverse in their structure and function, driving both beneficial and pathogenic responses depending on the location, strength, and duration of signaling. The following review will discuss all the aforementioned aspects of lipids at the host-pathogen interface, which should be expanded upon in future studies to develop novel therapeutics that consider lipids as distinct immune modulators.
Details
- Title: Subtitle
- Trimming the fat: a brief review of lipids at the host-pathogen interface
- Creators
- Filiz T. Korkmaz - ,
- Contributors
- Anthony R. Richardson (Editor)
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.93(7), e00506-24
- DOI
- 10.1128/iai.00506-24
- PMID
- 40512027
- PMCID
- PMC12234433
- NLM abbreviation
- Infect Immun
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Publisher
- American Society for Microbiology
- Number of pages
- 14
- Grant note
- R00HL159258 / National Heart, Lung, and Blood Institute (http://dx.doi.org/10.13039/100000050)
- Language
- English
- Electronic publication date
- 06/13/2025
- Date published
- 07/08/2025
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984829020502771
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