Journal article
Trolox C, a lipid-soluble membrane protective agent, attenuates myocardial injury from ischemia and reperfusion
Free radical biology & medicine, Vol.13(6), pp.627-634
12/01/1992
DOI: 10.1016/0891-5849(92)90037-H
PMID: 1459482
Abstract
The lipophilic antioxidant Trolox C, a vitamin E analog, was administered to isolated, buffer-perfused rabbit hearts subjected to 25 min of global stop-flow ischemia and 30 min of reperfusion. In six hearts, Trolox C (200 μM) was infused for 15 min immediately prior to ischemia and for the first 15 min of reperfusion. Six control hearts received only vehicle. Gas chromatography analysis confirmed that effective myocardial levels of Trolox were attained. At 30 min reperfusion, the recovery of left ventricular pressure was 56 ± 3% of baseline in control hearts versus 70 ± 4% in Trolox-treated hearts (p < .01). There was also significant improvement in recovery of Trolox-treated hearts in diastolic pressure and both maximum and minimum values of the first derivative of left ventricular pressure (dP/dt). Creatine phosphokinase release into the coronary effluent at 30 min of reperfusion was 16.5 ± 8.4 IU/min in untreated and 6.3 ± 1.0 IU/min (
p < .05) in Trolox-treated hearts. Thus Trolox C, a lipophilic antioxidant, attenuated myocardial injury during stop-flow ischemia and reperfusion.
Details
- Title: Subtitle
- Trolox C, a lipid-soluble membrane protective agent, attenuates myocardial injury from ischemia and reperfusion
- Creators
- Jeffrey D. Rubinstein - University of Colorado HealthEdward J. Lesnefsky - University of Colorado HealthRichard M. Byler - University of Colorado HealthPaul V. Fennessey - University of Colorado HealthLawrence D. Horwitz - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- Free radical biology & medicine, Vol.13(6), pp.627-634
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0891-5849(92)90037-H
- PMID
- 1459482
- ISSN
- 0891-5849
- eISSN
- 1873-4596
- Language
- English
- Date published
- 12/01/1992
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656538702771
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