Journal article
Troponin in COVID-19: To Measure or Not to Measure? Insights from a Prospective Cohort Study
Journal of clinical medicine, Vol.11(19), p.5951
10/09/2022
DOI: 10.3390/jcm11195951
PMID: 36233816
Abstract
Myocardial injury (MI), defined by troponin elevation, has been associated with increased mortality and adverse outcomes in patients with coronavirus disease 2019 (COVID-19), but the role of this biomarker as a risk predictor remains unclear. Data from adult patients hospitalized with COVID-19 were recorded prospectively. A multiple logistic regression model was used to quantify associations of all variables with in-hospital mortality, including the calculation of odds ratios (ORs) and confidence intervals (CI). Troponin measurement was performed in 1476 of 4628 included patients, and MI was detected in 353 patients, with a prevalence of 23.9%; [95% CI, 21.8-26.1%]. The total in-hospital mortality rate was 10.9% [95% CI, 9.8-12.0%]. The mortality was much higher among patients with MI than among those without MI, with a prevalence of 22.7% [95% CI, 18.5-27.3%] vs. 5.5% [95% CI, 4.3-7.0%] and increased with each troponin level. After adjustment for age and comorbidities, the model revealed that the mortality risk was greater for patients with MI [OR = 2.99; 95% CI, 2.06-4.36%], and for those who did not undergo troponin measurement [OR = 2.2; 95% CI, 1.62-2.97%], compared to those without MI. Our data support the role of troponin as an important risk predictor for these patients, capable of discriminating between those with a low or increased mortality rate. In addition, our findings suggest that this biomarker has a remarkable negative predictive value in COVID-19.
Details
- Title: Subtitle
- Troponin in COVID-19: To Measure or Not to Measure? Insights from a Prospective Cohort Study
- Creators
- Renata Moll-Bernardes - D’Or Institute for Research and EducationJoao D. Mattos - D’Or Institute for Research and EducationEduardo B. Schaustz - D’Or Institute for Research and EducationAndrea S. Sousa - DOr Inst Res & Educ, BR-22281100 Rio De Janeiro, BrazilJuliana R. Ferreira - D’Or Institute for Research and EducationMariana B. Tortelly - D’Or Institute for Research and EducationAdriana M. L. Pimentel - D’Or Institute for Research and EducationAna Cristina B. S. Figueiredo - D’Or Institute for Research and EducationMarcia M. Noya-Rabelo - D’Or Institute for Research and EducationAllan R. K. Sales - D’Or Institute for Research and EducationDenilson C. Albuquerque - DOr Inst Res & Educ, BR-22281100 Rio De Janeiro, BrazilPaulo H. Rosado-de-Castro - D’Or Institute for Research and EducationGabriel C. Camargo - D’Or Institute for Research and EducationOlga F. Souza - DOr Inst Res & Educ, BR-22281100 Rio De Janeiro, BrazilFernando A. Bozza - D’Or Institute for Research and EducationEmiliano Medei - D’Or Institute for Research and EducationRonir R. Luiz - D’Or Institute for Research and Education
- Resource Type
- Journal article
- Publication Details
- Journal of clinical medicine, Vol.11(19), p.5951
- DOI
- 10.3390/jcm11195951
- PMID
- 36233816
- NLM abbreviation
- J Clin Med
- ISSN
- 2077-0383
- eISSN
- 2077-0383
- Publisher
- Mdpi
- Number of pages
- 15
- Grant note
- E-26/210.155/2020; E-26/010.000149/2020; E-26/210.191/2020; E-26/210.253/2020 / Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro; Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) FINEP; Financiadora de Inovacao e Pesquisa (Finep) D'Or Institute of Research and Education 310681/2018-9 / CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) CAPES; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Serrapilheira Institute
- Language
- English
- Date published
- 10/09/2022
- Academic Unit
- Radiology
- Record Identifier
- 9985143550302771
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